SCOP 1.65: Domain d1nq2a_: 1nq2 A:

Lineage for d1nq2a_ (1nq2 A:)

1. Root: SCOP 1.65

2. Class a: All alpha proteins [46456] (179 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (1 family)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (25 proteins)

6. Protein Thyroid hormone receptor beta (TR-beta) [48530] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48531] (7 PDB entries)

8. Domain d1nq2a_: 1nq2 A: [86007]
   complexed with 4hy, ars, na; mutant

Details for d1nq2a_

PDB Entry: 1nq2, 2.4 Å

PDB Description: Two RTH Mutants with Impaired Hormone Binding

SCOP Domain Sequences for d1nq2a_:

Sequence, based on SEQRES records:

>d1nq2a_ a.123.1.1 (A:) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens)}
asaaeelqksighkpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqapivn
apeggkvdleafshftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslrt
avryepesetltlngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavl
lmssdrpglacveriekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachas
rflhmkvecptelfpplflevfe

Sequence, based on observed residues (ATOM records):

>d1nq2a_ a.123.1.1 (A:) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens)}
asaaeelqksighkpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqagkvd
leafshftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslrtavryepes
etltlngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpg
lacveriekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkve
cptelfpplflevfe

Timeline for d1nq2a_:

• d1nq2a_ is new in SCOP 1.65
  
• d1nq2a_ appears in SCOP 1.67
  
• d1nq2a_ appears in the current release, SCOPe 2.08, called d1nq2a1