SCOPe 2.08: Domain d1nq1a1: 1nq1 A:202-461

Lineage for d1nq1a1 (1nq1 A:202-461)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Thyroid hormone receptor beta (TR-beta) [48530] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48531] (22 PDB entries)
   Uniprot P10828 202-460

8. Domain d1nq1a1: 1nq1 A:202-461 [86006]
   Other proteins in same PDB: d1nq1a2
   complexed with 4hy, ars; mutant

Details for d1nq1a1

PDB Entry: 1nq1, 2.9 Å

PDB Description: tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the nterminal lbd

PDB Compounds: (A:) Thyroid hormone receptor Beta-1

SCOPe Domain Sequences for d1nq1a1:

Sequence, based on SEQRES records:

>d1nq1a1 a.123.1.1 (A:202-461) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens) [TaxId: 9606]}
eelqksighkpeptdeeweliktvteahvatnaqgshwkqkqkflpddigqapivnapeg
gkvdleafshftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavry
dpesetltlngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmss
drpglacveriekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflh
mkvecptelfpplflevfed

Sequence, based on observed residues (ATOM records):

>d1nq1a1 a.123.1.1 (A:202-461) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens) [TaxId: 9606]}
eelqksighkpeptdeeweliktvteahvatnaqgshwkqkqkflpddigqkvdleafsh
ftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltln
gemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacver
iekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecptelf
pplflevfed

Timeline for d1nq1a1:

• d1nq1a1 first appeared in SCOP 1.65, called d1nq1a_
  
• d1nq1a1 appears in SCOPe 2.07