Lineage for d1nq0a1 (1nq0 A:202-461)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2008476Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
    multihelical; 3 layers or orthogonally packed helices
  4. 2008477Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families) (S)
  5. 2008478Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 protein domains)
  6. 2009325Protein Thyroid hormone receptor beta (TR-beta) [48530] (1 species)
  7. 2009326Species Human (Homo sapiens) [TaxId:9606] [48531] (16 PDB entries)
    Uniprot P10828 202-460
  8. 2009331Domain d1nq0a1: 1nq0 A:202-461 [86005]
    Other proteins in same PDB: d1nq0a2
    complexed with 4hy, ars; mutant

Details for d1nq0a1

PDB Entry: 1nq0 (more details), 2.4 Å

PDB Description: TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD
PDB Compounds: (A:) Thyroid hormone receptor Beta-1

SCOPe Domain Sequences for d1nq0a1:

Sequence, based on SEQRES records: (download)

>d1nq0a1 a.123.1.1 (A:202-461) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens) [TaxId: 9606]}
eelqksighkpeptdeeweliktvteahvatntqgshwkqkrkflpedigqapivnapeg
gkvdleafshftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavry
dpesetltlngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmss
drpglacveriekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflh
mkvecptelfpplflevfed

Sequence, based on observed residues (ATOM records): (download)

>d1nq0a1 a.123.1.1 (A:202-461) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens) [TaxId: 9606]}
eelqksighkpeptdeeweliktvteahvatntqgshwkqkrkflpedigqkvdleafsh
ftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltln
gemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacver
iekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecptelf
pplflevfed

SCOPe Domain Coordinates for d1nq0a1:

Click to download the PDB-style file with coordinates for d1nq0a1.
(The format of our PDB-style files is described here.)

Timeline for d1nq0a1:

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Domains from same chain:
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d1nq0a2