SCOPe 2.05: Domain d1np0b1: 1np0 B:200-552

Lineage for d1np0b1 (1np0 B:200-552)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (15 families)

5. Family c.1.8.6: beta-N-acetylhexosaminidase catalytic domain [51550] (6 proteins)
   Glycosyl hydrolase family 20, GH20
   automatically mapped to Pfam PF00728

6. Protein beta-hexosaminidase B [89486] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89487] (6 PDB entries)

8. Domain d1np0b1: 1np0 B:200-552 [85942]
   Other proteins in same PDB: d1np0a2, d1np0b2
   complexed with gol, ngt, so4

Details for d1np0b1

PDB Entry: 1np0, 2.5 Å

PDB Description: human lysosomal beta-hexosaminidase isoform b in complex with intermediate analogue nag-thiazoline

PDB Compounds: (B:) beta-hexosaminidase beta chain

SCOPe Domain Sequences for d1np0b1:

Sequence, based on SEQRES records:

>d1np0b1 c.1.8.6 (B:200-552) beta-hexosaminidase B {Human (Homo sapiens) [TaxId: 9606]}
fshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqsitfpelsnkgs
yslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltpcysrqnkldsf
gpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtd
fkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsrvtas
gfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvdatnlt
prlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

Sequence, based on observed residues (ATOM records):

>d1np0b1 c.1.8.6 (B:200-552) beta-hexosaminidase B {Human (Homo sapiens) [TaxId: 9606]}
fshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqsitfpelsnkgs
yslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltpcysldsfgpin
ptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkkl
esfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpv
ilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlw
prasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

Timeline for d1np0b1:

• d1np0b1 first appeared in SCOP 1.65
  
• d1np0b1 appears in SCOPe 2.04
  
• d1np0b1 last appears in SCOPe 2.06