SCOP 1.71: Domain d1np0a1: 1np0 A:200-552

Lineage for d1np0a1 (1np0 A:200-552)

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (32 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (13 families)

5. Family c.1.8.6: beta-N-acetylhexosaminidase catalytic domain [51550] (3 proteins)
   Glycosyl hydrolase family 20, GH20

6. Protein beta-hexosaminidase B [89486] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89487] (4 PDB entries)

8. Domain d1np0a1: 1np0 A:200-552 [85940]
   Other proteins in same PDB: d1np0a2, d1np0b2

Details for d1np0a1

PDB Entry: 1np0, 2.5 Å

PDB Description: human lysosomal beta-hexosaminidase isoform b in complex with intermediate analogue nag-thiazoline

SCOP Domain Sequences for d1np0a1:

Sequence, based on SEQRES records:

>d1np0a1 c.1.8.6 (A:200-552) beta-hexosaminidase B {Human (Homo sapiens)}
fshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqsitfpelsnkgs
yslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltpcysrqnkldsf
gpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtd
fkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsrvtas
gfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvdatnlt
prlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

Sequence, based on observed residues (ATOM records):

>d1np0a1 c.1.8.6 (A:200-552) beta-hexosaminidase B {Human (Homo sapiens)}
fshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqsitfpelsnkgs
yslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltpcysldsfgpin
ptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkkl
esfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpv
ilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlw
prasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

Timeline for d1np0a1:

• d1np0a1 first appeared in SCOP 1.65
  
• d1np0a1 appears in SCOP 1.69
  
• d1np0a1 appears in SCOP 1.73
  
• d1np0a1 last appears in SCOPe 2.06