Lineage for d1ni4d1 (1ni4 D:1-191)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108430Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 protein domains)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
    automatically mapped to Pfam PF02779
  6. 2108468Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)
  7. 2108469Species Human (Homo sapiens) [TaxId:9606] [89653] (4 PDB entries)
  8. 2108473Domain d1ni4d1: 1ni4 D:1-191 [85732]
    Other proteins in same PDB: d1ni4a1, d1ni4a2, d1ni4b2, d1ni4b3, d1ni4c1, d1ni4c2, d1ni4d2, d1ni4d3
    complexed with k, mg, tpp

Details for d1ni4d1

PDB Entry: 1ni4 (more details), 1.95 Å

PDB Description: human pyruvate dehydrogenase
PDB Compounds: (D:) Pyruvate dehydrogenase E1 component: Beta subunit

SCOPe Domain Sequences for d1ni4d1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1ni4d1 c.36.1.7 (D:1-191) E1-beta subunit of pyruvate dehydrogenase, Pyr module {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1ni4d1:

Click to download the PDB-style file with coordinates for d1ni4d1.
(The format of our PDB-style files is described here.)

Timeline for d1ni4d1: