SCOPe 2.06: Domain d1nh3a1: 1nh3 A:431-626,A:719-765

Lineage for d1nh3a1 (1nh3 A:431-626,A:719-765)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
   core: alpha3-beta3-alpha4; one side of beta-sheet is exposed

4. Superfamily d.163.1: DNA breaking-rejoining enzymes [56349] (2 families)

5. Family d.163.1.2: Eukaryotic DNA topoisomerase I, catalytic core [56361] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, catalytic core [56362] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56363] (15 PDB entries)
   Uniprot P11387 203-765 ! Uniprot P11387 203-767

8. Domain d1nh3a1: 1nh3 A:431-626,A:719-765 [85710]
   Other proteins in same PDB: d1nh3a2
   protein/DNA complex

Details for d1nh3a1

PDB Entry: 1nh3, 3.1 Å

PDB Description: human topoisomerase i ara-c complex

PDB Compounds: (A:) DNA topoisomerase I

SCOPe Domain Sequences for d1nh3a1:

Sequence; same for both SEQRES and ATOM records:

>d1nh3a1 d.163.1.2 (A:431-626,A:719-765) Eukaryotic DNA topoisomerase I, catalytic core {Human (Homo sapiens) [TaxId: 9606]}
pssrikgekdwqkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalrag
nekeegetadtvgccslrvehinlhpeldgqeyvvefdflgkdsiryynkvpvekrvfkn
lqlfmenkqpeddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapde
nipakilsynranravXsklnyldpritvawckkwgvpiekiynktqrekfawaidmade
dyef

Timeline for d1nh3a1:

• d1nh3a1 first appeared in SCOP 1.65
  
• d1nh3a1 appears in SCOPe 2.05
  
• d1nh3a1 appears in SCOPe 2.07
  
• d1nh3a1 appears in the current release, SCOPe 2.08