SCOPe 2.08: Domain d1nava1: 1nav A:148-408

Lineage for d1nava1 (1nav A:148-408)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Thyroid hormone receptor alpha1 (TR-alpha1) [48532] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88962] (5 PDB entries)

8. Domain d1nava1: 1nav A:148-408 [85500]
   Other proteins in same PDB: d1nava2
   complexed with ih5, so4

Details for d1nava1

PDB Entry: 1nav, 2.5 Å

PDB Description: Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1

PDB Compounds: (A:) hormone receptor alpha 1, THRA1

SCOPe Domain Sequences for d1nava1:

Sequence, based on SEQRES records:

>d1nava1 a.123.1.1 (A:148-408) Thyroid hormone receptor alpha1 (TR-alpha1) {Human (Homo sapiens) [TaxId: 9606]}
eemirslqqrpeptpeewdlihiateahrstnaqgshwkqrrkflpddigqspivsmpdg
dkvdleafseftkiitpaitrvvdfakklpmfselpcedqiillkgccmeimslraavry
dpesdtltlsgemavkreqlkngglgvvsdaifelgkslsafnlddtevallqavllmst
drsgllcvdkieksqeayllafehyvnhrkhniphfwpkllmkvtdlrmigachasrflh
mkvecptelfpplflevfedq

Sequence, based on observed residues (ATOM records):

>d1nava1 a.123.1.1 (A:148-408) Thyroid hormone receptor alpha1 (TR-alpha1) {Human (Homo sapiens) [TaxId: 9606]}
eemirslqqrpeptpeewdlihiateahrstnakqrrkflpddigqspdgdkvdleafse
ftkiitpaitrvvdfakklpmfselpcedqiillkgccmeimslraavrydpesdtltls
gemavkreqlkngglgvvsdaifelgkslsafnlddtevallqavllmstdrsgllcvdk
ieksqeayllafehyvnhrkhniphfwpkllmkvtdlrmigachasrflhmkvecptelf
pplflevfedq

Timeline for d1nava1:

• d1nava1 first appeared in SCOP 1.65, called d1nava_
  
• d1nava1 appears in SCOPe 2.07