Lineage for d1n46b_ (1n46 B:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2008476Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
    multihelical; 3 layers or orthogonally packed helices
  4. 2008477Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families) (S)
  5. 2008478Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 protein domains)
  6. 2009325Protein Thyroid hormone receptor beta (TR-beta) [48530] (1 species)
  7. 2009326Species Human (Homo sapiens) [TaxId:9606] [48531] (16 PDB entries)
    Uniprot P10828 202-460
  8. 2009329Domain d1n46b_: 1n46 B: [85316]
    complexed with pfa

Details for d1n46b_

PDB Entry: 1n46 (more details), 2.2 Å

PDB Description: crystal structure of human tr beta ligand-binding domain complexed with a potent subtype-selective thyromimetic
PDB Compounds: (B:) Thyroid hormone receptor Beta-1

SCOPe Domain Sequences for d1n46b_:

Sequence, based on SEQRES records: (download)

>d1n46b_ a.123.1.1 (B:) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens) [TaxId: 9606]}
kpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqapivnapeggkvdleafs
hftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltl
ngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacve
riekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecptel
fpplflevfed

Sequence, based on observed residues (ATOM records): (download)

>d1n46b_ a.123.1.1 (B:) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens) [TaxId: 9606]}
kpeptdeeweliktvteahvatnaqwkqkrkflpedigqakvdleafshftkiitpaitr
vvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltlngemavtrgqlk
ngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacveriekyqdsflla
fehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecptelfpplflevfed

SCOPe Domain Coordinates for d1n46b_:

Click to download the PDB-style file with coordinates for d1n46b_.
(The format of our PDB-style files is described here.)

Timeline for d1n46b_: