SCOP 1.71: Domain d1mzcb_: 1mzc B:

Lineage for d1mzcb_ (1mzc B:)

1. Root: SCOP 1.71

2. Class a: All alpha proteins [46456] (226 folds)

3. Fold a.102: alpha/alpha toroid [48207] (5 superfamilies)
   multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies

4. Superfamily a.102.4: Terpenoid cyclases/Protein prenyltransferases [48239] (4 families)

5. Family a.102.4.3: Protein prenyltransferases [48246] (2 proteins)

6. Protein Protein farnesyltransferase, beta-subunit [48247] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [69090] (14 PDB entries)

8. Domain d1mzcb_: 1mzc B: [85240]
   Other proteins in same PDB: d1mzca_
   complexed with bne, fpp, suc, zn

Details for d1mzcb_

PDB Entry: 1mzc, 2 Å

PDB Description: co-crystal structure of human farnesyltransferase with farnesyldiphosphate and inhibitor compound 33a

SCOP Domain Sequences for d1mzcb_:

Sequence; same for both SEQRES and ATOM records:

>d1mzcb_ a.102.4.3 (B:) Protein farnesyltransferase, beta-subunit {Human (Homo sapiens)}
pvwseplyslrpeharerlqddsvetvtsieqakveekiqevfssykfnhlvprlvlqre
khfhylkrglrqltdayecldasrpwlcywilhslelldepipqivatdvcqflelcqsp
eggfgggpgqyphlaptyaavnalciigteeaydiinrekllqylyslkqpdgsflmhvg
gevdvrsaycaasvasltniitpdlfegtaewiarcqnweggiggvpgmeahggytfcgl
aalvilkrerslnlksllqwvtsrqmrfeggfqgrcnklvdgcysfwqagllpllhralh
aqgdpalsmshwmfhqqalqeyilmccqcpagglldkpgksrdfyhtcyclsglsiaqhf
gsgamlhdvvlgvpenalqpthpvynigpdkviqattyflqkpvpgf

Timeline for d1mzcb_:

• d1mzcb_ first appeared in SCOP 1.65
  
• d1mzcb_ appears in SCOP 1.69
  
• d1mzcb_ appears in SCOP 1.73
  
• d1mzcb_ appears in the current release, SCOPe 2.08