SCOPe 2.06: Domain d1mx5f_: 1mx5 F:

Lineage for d1mx5f_ (1mx5 F:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins)
   automatically mapped to Pfam PF00135

6. Protein Mammalian carboxylesterase (liver carboxylesterase I) [75282] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89768] (7 PDB entries)

8. Domain d1mx5f_: 1mx5 F: [85176]
   complexed with cl, htq, nag, ndg, sia

Details for d1mx5f_

PDB Entry: 1mx5, 2.8 Å

PDB Description: crystal structure of human liver carboxylesterase in complexed with homatropine, a cocaine analogue

PDB Compounds: (F:) liver Carboxylesterase I

SCOPe Domain Sequences for d1mx5f_:

Sequence; same for both SEQRES and ATOM records:

>d1mx5f_ c.69.1.1 (F:) Mammalian carboxylesterase (liver carboxylesterase I) {Human (Homo sapiens) [TaxId: 9606]}
sppvvdtvhgkvlgkfvslegfaqpvaiflgipfakpplgplrftppqpaepwsfvknat
syppmctqdpkagqllselftnrkeniplklsedclylniytpadltkknrlpvmvwihg
gglmvgaastydglalaahenvvvvtiqyrlgiwgffstgdehsrgnwghldqvaalrwv
qdniasfggnpgsvtifgesaggesvsvlvlsplaknlfhraisesgvaltsvlvkkgdv
kplaeqiaitagcktttsavmvhclrqkteeellettlkmkflsldlqgdpresqpllgt
vidgmlllktpeelqaernfhtvpymvginkqefgwlipmlmsyplsegqldqktamsll
wksyplvciakelipeatekylggtddtvkkkdlfldliadvmfgvpsvivarnhrdaga
ptymyefqyrpsfssdmkpktvigdhgdelfsvfgapflkegaseeeirlskmvmkfwan
farngnpngeglphwpeynqkegylqigantqaaqklkdkevafwtnlfak

Timeline for d1mx5f_:

• d1mx5f_ first appeared in SCOP 1.65
  
• d1mx5f_ appears in SCOPe 2.05
  
• d1mx5f_ appears in SCOPe 2.07
  
• d1mx5f_ appears in the current release, SCOPe 2.08