Lineage for d1mvta_ (1mvt A:)

  1. Root: SCOP 1.65
  2. 305035Class c: Alpha and beta proteins (a/b) [51349] (121 folds)
  3. 320020Fold c.71: Dihydrofolate reductases [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 320021Superfamily c.71.1: Dihydrofolate reductases [53597] (1 family) (S)
  5. 320022Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)
  6. 320113Protein Dihydrofolate reductases, eukaryotic type [53605] (4 species)
  7. 320135Species Human (Homo sapiens) [TaxId:9606] [53607] (15 PDB entries)
  8. 320138Domain d1mvta_: 1mvt A: [85157]
    complexed with dtm, so4

Details for d1mvta_

PDB Entry: 1mvt (more details), 1.8 Å

PDB Description: analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine n9-c10 reverse-bridge antifolate binary complex with human dihydrofolate reductase

SCOP Domain Sequences for d1mvta_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1mvta_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens)}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

SCOP Domain Coordinates for d1mvta_:

Click to download the PDB-style file with coordinates for d1mvta_.
(The format of our PDB-style files is described here.)

Timeline for d1mvta_: