Lineage for d1mhpx_ (1mhp X:)

  1. Root: SCOP 1.71
  2. 546417Class b: All beta proteins [48724] (149 folds)
  3. 546418Fold b.1: Immunoglobulin-like beta-sandwich [48725] (25 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 546419Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 546420Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (28 proteins)
  6. 546556Protein Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 546557Species Engineered (including hybrid species) [88562] (52 PDB entries)
  8. 546605Domain d1mhpx_: 1mhp X: [84971]
    Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph2, d1mhpl1, d1mhpl2, d1mhpy_
    part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered
    complexed with mn; mutant

Details for d1mhpx_

PDB Entry: 1mhp (more details), 2.8 Å

PDB Description: crystal structure of a chimeric alpha1 integrin i-domain in complex with the fab fragment of a humanized neutralizing antibody

SCOP Domain Sequences for d1mhpx_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1mhpx_ b.1.1.1 (X:) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)}
evqlvesggglvqpggslrlscaasgftfsrytmswvrqapgkglewvatisggghtyyl
dsvkgrftisrdnskntlylqmnslraedtavyyctrgfgdggyfdvwgqgtlvtvss

SCOP Domain Coordinates for d1mhpx_:

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Timeline for d1mhpx_: