SCOPe 2.05: Domain d1mdwa_: 1mdw A:

Lineage for d1mdwa_ (1mdw A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.3: Calpain large subunit, catalytic domain (domain II) [54040] (1 protein)
   automatically mapped to Pfam PF00648

6. Protein Calpain large subunit, catalytic domain (domain II) [54041] (6 species)
   includes the N-terminal 'sequence' domain I

7. Species Norway rat (Rattus norvegicus), M-type [TaxId:10116] [54043] (3 PDB entries)

8. Domain d1mdwa_: 1mdw A: [84934]
   calcium-bound protease core
   complexed with ca

Details for d1mdwa_

PDB Entry: 1mdw, 1.95 Å

PDB Description: crystal structure of calcium-bound protease core of calpain ii reveals the basis for intrinsic inactivation

PDB Compounds: (A:) Calpain II, catalytic subunit

SCOPe Domain Sequences for d1mdwa_:

Sequence, based on SEQRES records:

>d1mdwa_ d.3.1.3 (A:) Calpain large subunit, catalytic domain (domain II) {Norway rat (Rattus norvegicus), M-type [TaxId: 10116]}
eraikylnqdyetlrnecleagalfqdpsfpalpsslgfkelgpyssktrgiewkrptei
cadpqfiiggatrtdicqgalgdswllaaiasltlneeilarvvpldqsfqenyagifhf
qfwqygewvevvvddrlptkdgellfvhsaegsefwsallekayakingcyealsggatt
egfedftggiaewyelrkpppnlfkiiqkalekgsllgcsiditsaadseavtyqklvkg
haysvtgaeevessgslqklirirnpwgqvewtgkwndncpswntvdpevranlterqed
gefwmsfsdflrhysrleicnlt

Sequence, based on observed residues (ATOM records):

>d1mdwa_ d.3.1.3 (A:) Calpain large subunit, catalytic domain (domain II) {Norway rat (Rattus norvegicus), M-type [TaxId: 10116]}
eraikylnqdyetlrnecleagalfqdpsfpalpsslgfkelgpyssktrgiewkrptei
cadpqfiiggatrtdicqgalgdswllaaiasltlneeilarvvpldqsfqenyagifhf
qfwqygewvevvvddrlptkdgellfvhsaegsefwsallekayakingcyealsgegfe
dftggiaewyelrkpppnlfkiiqkalekgsllgcsiditsaadseavtyqklvkghays
vtgaeevessgslqklirirnpwgqvewtgkwndncpswntvdpevranlterqedgefw
msfsdflrhysrleicnlt

Timeline for d1mdwa_:

• d1mdwa_ first appeared in SCOP 1.65
  
• d1mdwa_ appears in SCOPe 2.04
  
• d1mdwa_ appears in SCOPe 2.06
  
• d1mdwa_ appears in the current release, SCOPe 2.08