SCOPe 2.08: Domain d1m2ka1: 1m2k A:1-245

Lineage for d1m2ka1 (1m2k A:1-245)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein AF1676, Sir2 homolog (Sir2-AF1?) [63985] (1 species)

7. Species Archaeoglobus fulgidus [TaxId:2234] [63986] (6 PDB entries)

8. Domain d1m2ka1: 1m2k A:1-245 [84754]
   Other proteins in same PDB: d1m2ka2
   complexed with apr, zn; mutant

Details for d1m2ka1

PDB Entry: 1m2k, 1.47 Å

PDB Description: sir2 homologue f159a mutant-adp ribose complex

PDB Compounds: (A:) Silent Information Regulator 2

SCOPe Domain Sequences for d1m2ka1:

Sequence; same for both SEQRES and ATOM records:

>d1m2ka1 c.31.1.5 (A:1-245) AF1676, Sir2 homolog (Sir2-AF1?) {Archaeoglobus fulgidus [TaxId: 2234]}
mdekllktiaeskylvaltgagvsaesgiptfrgkdglwnryrpeelanpqafakdpekv
wkwyawrmekvfnaqpnkahqafaelerlgvlkclitqnvddlheragsrnvihlhgslr
vvrctscnnsfevesapkipplpkcdkcgsllrpgvvwagemlppdvldramreveradv
iivagtsavvqpaaslplivkqrggaiieinpdetpltpiadyslrgkagevmdelvrhv
rkals

Timeline for d1m2ka1:

• d1m2ka1 first appeared in SCOP 1.65, called d1m2ka_
  
• d1m2ka1 appears in SCOPe 2.07