SCOPe 2.08: Domain d1jcnb1: 1jcn B:10-111,B:232-499

Lineage for d1jcnb1 (1jcn B:10-111,B:232-499)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (2 families)
   The phosphate moiety of substrate binds in the 'common' phosphate-binding site

5. Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)

6. Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (8 species)

7. Species Human (Homo sapiens), type I [TaxId:9606] [89456] (1 PDB entry)

8. Domain d1jcnb1: 1jcn B:10-111,B:232-499 [84163]
   Other proteins in same PDB: d1jcna4, d1jcnb4
   contains two CBS domains inserted into the common fold, residues 111-231
   complexed with cpr

Details for d1jcnb1

PDB Entry: 1jcn, 2.5 Å

PDB Description: binary complex of human type-i inosine monophosphate dehydrogenase with 6-cl-imp

PDB Compounds: (B:) inosine monophosphate dehydrogenase I

SCOPe Domain Sequences for d1jcnb1:

Sequence, based on SEQRES records:

>d1jcnb1 c.1.5.1 (B:10-111,B:232-499) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type I [TaxId: 9606]}
tgyvpedgltaqqlfasaddltyndflilpgfidfiadevdltsaltrkitlktplissp
mdtvteadmaiamalmggigfihhnctpefqanevrkvknfeXdyplaskdsqkqllcga
avgtreddkyrldlltqagvdvivldssqgnsvyqiamvhyikqkyphlqviggnvvtaa
qaknlidagvdglrvgmgcgsicitqevmacgrpqgtavykvaeyarrfgvpiiadggiq
tvghvvkalalgastvmmgsllaatteapgeyffsdgvrlkkyrgmgsldamekssssqk
ryfsegdkvkiaqgvsgsiqdkgsiqkfvpyliagiqhgcqdigarslsvlrsmmysgel
kfekrtmsaqi

Sequence, based on observed residues (ATOM records):

>d1jcnb1 c.1.5.1 (B:10-111,B:232-499) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type I [TaxId: 9606]}
tgyvpedgltaqqlfasaddltyndflilpgfidfiadevdltsaltrkitlktplissp
mdtvteadmaiamalmggigfihhnctpefqanevrkvknfeXdyplaskdsqkqllcga
avgtreddkyrldlltqagvdvivldssqgnsvyqiamvhyikqkyphlqviggnvvtaa
qaknlidagvdglrvgmgcgsicitqevmacgrpqgtavykvaeyarrfgvpiiadggiq
tvghvvkalalgastvmmgsllaatteapgekgsiqkfvpyliagiqhgcqdigarslsv
lrsmmysgelkfekrtmsaqi

Timeline for d1jcnb1:

• d1jcnb1 first appeared in SCOP 1.65
  
• d1jcnb1 appears in SCOPe 2.07