SCOP 1.73: Domain d1j3ja_: 1j3j A:

Lineage for d1j3ja_ (1j3j A:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (3 PDB entries)

8. Domain d1j3ja_: 1j3j A: [84066]
   Other proteins in same PDB: d1j3jc_, d1j3jd_

Details for d1j3ja_

PDB Entry: 1j3j, 2.3 Å

PDB Description: double mutant (c59r+s108n) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with pyrimethamine, nadph, and dump

PDB Compounds: (A:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOP Domain Sequences for d1j3ja_:

Sequence, based on SEQRES records:

>d1j3ja_ c.71.1.1 (A:) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcnsldmkyfra
vttyvneskyeklkykrckylnketvdnvndmpnskklqnvvvmgrtnwesipkkfkpls
nrinvilsrtlkkedfdedvyiinkvedlivllgklnyykcfiiggsvvyqeflekklik
kiyftrinstyecdvffpeineneyqiisvsdvytsnnttldfiiykktnn

Sequence, based on observed residues (ATOM records):

>d1j3ja_ c.71.1.1 (A:) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcnsldmkyfra
vttyvneskyeklkykrckylnketkklqnvvvmgrtnwesipkkfkplsnrinvilsrt
lkkedfdedvyiinkvedlivllgklnyykcfiiggsvvyqeflekklikkiyftrinst
yecdvffpeineneyqiisvsdvytsnnttldfiiykktnn

Timeline for d1j3ja_:

• d1j3ja_ first appeared in SCOP 1.65
  
• d1j3ja_ appears in SCOP 1.71
  
• d1j3ja_ appears in SCOP 1.75
  
• d1j3ja_ appears in the current release, SCOPe 2.08