Lineage for d1gz3c1 (1gz3 C:280-573)

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1826588Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 1826589Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 1830007Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 protein domains)
    extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site
  6. 1830158Protein Mitochondrial NAD(P)-dependent malic enzyme [51898] (3 species)
    includes C-terminal additional subdomains
  7. 1830176Species Human (Homo sapiens) [TaxId:9606] [51899] (10 PDB entries)
  8. 1830183Domain d1gz3c1: 1gz3 C:280-573 [83397]
    Other proteins in same PDB: d1gz3a2, d1gz3b2, d1gz3c2, d1gz3d2
    complexed with atp, fum, mn, oxl

Details for d1gz3c1

PDB Entry: 1gz3 (more details), 2.3 Å

PDB Description: molecular mechanism for the regulation of human mitochondrial nad(p)+-dependent malic enzyme by atp and fumarate
PDB Compounds: (C:) NAD-dependent malic enzyme

SCOPe Domain Sequences for d1gz3c1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1gz3c1 c.2.1.7 (C:280-573) Mitochondrial NAD(P)-dependent malic enzyme {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1gz3c1:

Click to download the PDB-style file with coordinates for d1gz3c1.
(The format of our PDB-style files is described here.)

Timeline for d1gz3c1: