SCOPe 2.05: Domain d1gz3a2: 1gz3 A:20-279

Lineage for d1gz3a2 (1gz3 A:20-279)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.58: Aminoacid dehydrogenase-like, N-terminal domain [53222] (1 superfamily)
   core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134

4. Superfamily c.58.1: Aminoacid dehydrogenase-like, N-terminal domain [53223] (6 families)

5. Family c.58.1.3: Malic enzyme N-domain [53240] (2 proteins)
   Pfam PF00390; decorated with additional structures; includes N-terminal additional subdomains and extra N-terminal strand

6. Protein Mitochondrial NAD(P)-dependent malic enzyme [53241] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53242] (10 PDB entries)

8. Domain d1gz3a2: 1gz3 A:20-279 [83394]
   Other proteins in same PDB: d1gz3a1, d1gz3b1, d1gz3c1, d1gz3d1
   complexed with atp, fum, mn, oxl

Details for d1gz3a2

PDB Entry: 1gz3, 2.3 Å

PDB Description: molecular mechanism for the regulation of human mitochondrial nad(p)+- dependent malic enzyme by atp and fumarate

PDB Compounds: (A:) NAD-dependent malic enzyme

SCOPe Domain Sequences for d1gz3a2:

Sequence; same for both SEQRES and ATOM records:

>d1gz3a2 c.58.1.3 (A:20-279) Mitochondrial NAD(P)-dependent malic enzyme {Human (Homo sapiens) [TaxId: 9606]}
hikekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspl
ekyiyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisd
rghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdqcl
pvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgn
hnafrflrkyrekyctfndd

Timeline for d1gz3a2:

• d1gz3a2 first appeared in SCOP 1.65
  
• d1gz3a2 appears in SCOPe 2.04
  
• d1gz3a2 appears in SCOPe 2.06
  
• d1gz3a2 appears in the current release, SCOPe 2.08