SCOP 1.71: Domain d1e1h.2: 1e1h C:,D:

Lineage for d1e1h.2 (1e1h C:,D:)

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (15 families)

5. Family d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (1 protein)

6. Protein Botulinum neurotoxin [55513] (3 species)

7. Species Clostridium botulinum, serotype A [TaxId:1491] [55514] (4 PDB entries)

8. Domain d1e1h.2: 1e1h C:,D: [83168]
   catalytic domain only; cleaved
   complexed with zn; mutant

Details for d1e1h.2

PDB Entry: 1e1h, 1.8 Å

PDB Description: crystal structure of recombinant botulinum neurotoxin type a light chain, self-inhibiting zn endopeptidase.

SCOP Domain Sequences for d1e1h.2:

Sequence, based on SEQRES records:

>g1e1h.2 d.92.1.7 (C:,D:) Botulinum neurotoxin {Clostridium botulinum, serotype A}
maykdpvngvdiayikipnagqmqpvkafkihnkiwviperdtftnpeegdlnpppeakq
vpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwggstidtel
kvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghdvlnltrngygstqyir
fspdftfgfeeslevdtnpllgagkfatdpavtlahelihaehrlygiainpnrvfkvnt
nayXyemsglevsfeelrtfgghdakfidslqenefrlyyynkfkdvastlnkaksiigt
taslqymknvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvnffkvinrkty
lnfdkavfrinivpdenytikdgfnlkganlstnfngqnteinsrnftrl

Sequence, based on observed residues (ATOM records):

>g1e1h.2 d.92.1.7 (C:,D:) Botulinum neurotoxin {Clostridium botulinum, serotype A}
maykdpvngvdiayikipnagqmqpvkafkihnkiwviperdtftnpeegdlnpppeakq
vpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwggstidtel
kvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghdvlnltrngygstqyir
fspdftfgfeeslgagkfatdpavtlahelihaehrlygiainpnrvfkvntnayXyems
glevsfeelrtfgghdakfidslqenefrlyyynkfkdvastlnkaksiigttaslqymk
nvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvnffkvinrktylnfdkavf
rinivpdenytikdgfnlkanlstnfngqnteinsrnftrl

Timeline for d1e1h.2:

• d1e1h.2 first appeared in SCOP 1.65
  
• d1e1h.2 appears in SCOP 1.69
  
• d1e1h.2 appears in SCOP 1.73
  
• d1e1h.2 appears in the current release, SCOPe 2.08