SCOPe 2.01: Protein: Angiotensin converting enzyme, ACE

Lineage for Protein: Angiotensin converting enzyme, ACE

Root: SCOPe 2.01
Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
Fold d.92: Zincin-like [55485] (2 superfamilies)
contains mixed beta sheet with connection over free side of the sheet
Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

Family d.92.1.5: Neurolysin-like [55505] (5 proteins)
combines M2, M3 and M32 families of metalloproteases
the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

Protein Angiotensin converting enzyme, ACE [82733] (2 species)
M2 family member; overall fold is similar to that of neurolysin but is less elaborated

Species:

Fruit fly (Drosophila melanogaster) [TaxId:7227] [89991] (3 PDB entries)
1. Domains for 1j36:
  1. Domain d1j36a_: 1j36 A: [84054]
    complexed with lpr, zn
  2. Domain d1j36b_: 1j36 B: [84055]
    complexed with lpr, zn
2. Domains for 1j37:
  1. Domain d1j37a_: 1j37 A: [84056]
    complexed with mco, zn
  2. Domain d1j37b_: 1j37 B: [84057]
    complexed with mco, zn
3. Domains for 1j38:
  1. Domain d1j38a_: 1j38 A: [84058]
    complexed with zn
  2. Domain d1j38b_: 1j38 B: [84059]
    complexed with zn
Human (Homo sapiens) [TaxId:9606] [82734] (9 PDB entries)
Uniprot P22966
1. Domain for 1o86:
  - Domain d1o86a_: 1o86 A: [81177]
    complexed with cl, gly, lpr, zn
2. Domain for 1o8a:
  - Domain d1o8aa_: 1o8a A: [81179]
    complexed with act, cl, nag, ndg, nxa, zn
3. Domain for 1uze:
  - Domain d1uzea_: 1uze A: [108174]
    complexed with cl, eal, gly, zn
4. Domain for 1uzf:
  - Domain d1uzfa_: 1uzf A: [108175]
    complexed with cl, mco, nag, zn
5. Domain for 2oc2:
  - Domain d2oc2a_: 2oc2 A: [139007]
    automated match to d1o86a_
    complexed with cl, rx3, zn
6. Domain for 2xy9:
  - Domain d2xy9a_: 2xy9 A: [170474]
    automated match to d1o86a_
    complexed with 3es, act, cl, epe, nag, zn
7. Domain for 3bkk:
  - Domain d3bkka_: 3bkk A: [172679]
    automated match to d1o86a_
    complexed with cl, kaf, nag, zn
8. Domain for 3bkl:
  - Domain d3bkla_: 3bkl A: [172680]
    automated match to d1o86a_
    complexed with act, cl, gol, kaw, nag, zn
9. Domain for 3l3n:
  - Domain d3l3na_: 3l3n A: [179912]
    automated match to d1o86a_
    complexed with cl, lsw, zn

More info for Protein Angiotensin converting enzyme, ACE from d.92.1.5: Neurolysin-like

Timeline for Protein Angiotensin converting enzyme, ACE from d.92.1.5: Neurolysin-like:

Protein Angiotensin converting enzyme, ACE from d.92.1.5: Neurolysin-like first appeared in SCOP 1.63, called Protein Angiotensin convering enzyme from d.92.1.5: Neurolysin-like
Protein Angiotensin converting enzyme, ACE from d.92.1.5: Neurolysin-like appears in SCOP 1.75
Protein Angiotensin converting enzyme, ACE from d.92.1.5: Neurolysin-like appears in SCOPe 2.02
Protein Angiotensin converting enzyme, ACE from d.92.1.5: Neurolysin-like appears in the current release, SCOPe 2.08