SCOPe 2.01: Family c.77.1.2: Monomeric isocitrate dehydrogenase

Lineage for Family c.77.1.2: Monomeric isocitrate dehydrogenase

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.2: Monomeric isocitrate dehydrogenase [82526] (2 proteins)
   the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion

Proteins:

1. Monomeric isocitrate dehydrogenase [82527] (1 species)

   • Species Azotobacter vinelandii [TaxId:354] [82528] (1 PDB entry)
     the insert region spans residues 150-404

2. automated matches [190493] (2 species)
   not a true protein

   1. Species Corynebacterium glutamicum [TaxId:1718] [187435] (1 PDB entry)

   2. Species Corynebacterium glutamicum [TaxId:196627] [189781] (1 PDB entry)

More info for Family c.77.1.2: Monomeric isocitrate dehydrogenase

Timeline for Family c.77.1.2: Monomeric isocitrate dehydrogenase:

• Family c.77.1.2: Monomeric isocitrate dehydrogenase first appeared in SCOP 1.63
  
• Family c.77.1.2: Monomeric isocitrate dehydrogenase appears in SCOP 1.75
  
• Family c.77.1.2: Monomeric isocitrate dehydrogenase appears in SCOPe 2.02
  
• Family c.77.1.2: Monomeric isocitrate dehydrogenase appears in the current release, SCOPe 2.08