Lineage for Family c.77.1.2: Monomeric isocitrate dehydrogenase

  1. Root: SCOP 1.69
  2. 473232Class c: Alpha and beta proteins (a/b) [51349] (136 folds)
  3. 493010Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 493011Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (5 families) (S)
    the constituent families form similar dimers
  5. 493100Family c.77.1.2: Monomeric isocitrate dehydrogenase [82526] (1 protein)
    the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion

Protein:

More info for Family c.77.1.2: Monomeric isocitrate dehydrogenase

Timeline for Family c.77.1.2: Monomeric isocitrate dehydrogenase: