Lineage for Protein: NADP-dependent isocitrate dehydrogenase

  1. Root: SCOPe 2.07
  2. 2434694Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2513202Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2513203Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2513204Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
    the active site is between the two identical subunits
  6. 2513298Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

Species:

  1. 2513299Human (Homo sapiens) [TaxId:9606] [110715] (31 PDB entries)
    Uniprot O75874
    1. Domains for 1t09:
      1. 2513328Domain d1t09a_: 1t09 A: [106197]
        complexed with nap
      2. 2513329Domain d1t09b_: 1t09 B: [106198]
        complexed with nap
    2. Domains for 1t0l:
      1. 2513306Domain d1t0la_: 1t0l A: [106216]
        complexed with ca, ict, nap
      2. 2513307Domain d1t0lb_: 1t0l B: [106217]
        complexed with ca, ict, nap
      3. 2513308Domain d1t0lc_: 1t0l C: [106218]
        complexed with ca, ict, nap
      4. 2513309Domain d1t0ld_: 1t0l D: [106219]
        complexed with ca, ict, nap
    3. Domains for 3inm:
      1. 2513325Domain d3inma_: 3inm A: [178460]
        automated match to d1t09a_
        protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant
      2. 2513326Domain d3inmb_: 3inm B: [178461]
        automated match to d1t09a_
        protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant
      3. 2513327Domain d3inmc_: 3inm C: [178462]
        automated match to d1t09a_
        protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant
    4. Domains for 3map:
      1. 2513382Domain d3mapa_: 3map A: [180990]
        automated match to d1t09a_
        complexed with ict, nap; mutant
      2. 2513383Domain d3mapb_: 3map B: [180991]
        automated match to d1t09a_
        complexed with ict, nap; mutant
    5. Domains for 4kzo:
      1. 2513303Domain d4kzoa1: 4kzo A:3-414 [224533]
        Other proteins in same PDB: d4kzoa2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
      2. 2513304Domain d4kzob_: 4kzo B: [224534]
        Other proteins in same PDB: d4kzoa2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
      3. 2513305Domain d4kzoc_: 4kzo C: [224535]
        Other proteins in same PDB: d4kzoa2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
    6. Domains for 4l03:
      1. 2513318Domain d4l03a1: 4l03 A:3-414 [224536]
        Other proteins in same PDB: d4l03a2, d4l03c2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
      2. 2513319Domain d4l03b_: 4l03 B: [224537]
        Other proteins in same PDB: d4l03a2, d4l03c2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
      3. 2513320Domain d4l03c1: 4l03 C:3-414 [224538]
        Other proteins in same PDB: d4l03a2, d4l03c2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
    7. Domains for 4l04:
      1. 2513387Domain d4l04a1: 4l04 A:5-414 [240460]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d4l04b_
        complexed with akg, ca, nap; mutant
      2. 2513388Domain d4l04b_: 4l04 B: [235250]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d1t0la_
        complexed with akg, ca, nap; mutant
      3. 2513389Domain d4l04c1: 4l04 C:4-414 [240461]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d4l04b_
        complexed with akg, ca, nap; mutant
      4. 2513390Domain d4l04d_: 4l04 D: [240462]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d4l04b_
        complexed with akg, ca, nap; mutant
      5. 2513391Domain d4l04e1: 4l04 E:4-414 [240463]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d4l04b_
        complexed with akg, ca, nap; mutant
      6. 2513392Domain d4l04f_: 4l04 F: [240464]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d4l04b_
        complexed with akg, ca, nap; mutant
    8. Domains for 4l06:
      1. 2513351Domain d4l06a1: 4l06 A:3-414 [224539]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
      2. 2513352Domain d4l06b_: 4l06 B: [224540]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
      3. 2513353Domain d4l06c_: 4l06 C: [224541]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
      4. 2513354Domain d4l06d_: 4l06 D: [224542]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
      5. 2513355Domain d4l06e1: 4l06 E:3-414 [224543]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
      6. 2513356Domain d4l06f_: 4l06 F: [224544]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
    9. Domains for 5de1:
      1. 2513347Domain d5de1a_: 5de1 A: [277861]
        automated match to d1t0la_
        complexed with 59d, nap
      2. 2513348Domain d5de1b_: 5de1 B: [277860]
        automated match to d1t0la_
        complexed with 59d, nap
    10. Domain for 5l57:
    11. Domain for 5l58:
    12. Domains for 5lge:
      1. 2513377Domain d5lgea1: 5lge A:3-414 [329495]
        Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
        automated match to d1t0la_
        complexed with 6vn, act, edo, nap; mutant
      2. 2513378Domain d5lgeb1: 5lge B:3-414 [329476]
        Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
        automated match to d1t0la_
        complexed with 6vn, act, edo, nap; mutant
      3. 2513379Domain d5lgec1: 5lge C:2-414 [329478]
        Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
        automated match to d1t0la_
        complexed with 6vn, act, edo, nap; mutant
      4. 2513380Domain d5lged1: 5lge D:3-414 [329511]
        Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
        automated match to d1t0la_
        complexed with 6vn, act, edo, nap; mutant
    13. Domains for 5sun:
      1. 2513368Domain d5suna_: 5sun A: [329541]
        automated match to d1t0la_
        complexed with 70q, dms, edo, ndp, so4
      2. 2513369Domain d5sunb_: 5sun B: [329522]
        automated match to d1t0la_
        complexed with 70q, dms, edo, ndp, so4
    14. Domains for 5svf:
      1. 2513361Domain d5svfa_: 5svf A: [329571]
        automated match to d1t0la_
        complexed with 70p, flc, ndp
      2. 2513362Domain d5svfb_: 5svf B: [329533]
        automated match to d1t0la_
        complexed with 70p, flc, ndp
      3. 2513363Domain d5svfc_: 5svf C: [329524]
        automated match to d1t0la_
        complexed with 70p, flc, ndp
      4. 2513364Domain d5svfd_: 5svf D: [329530]
        automated match to d1t0la_
        complexed with 70p, flc, ndp
    15. Domains for 5tqh:
      1. 2513343Domain d5tqha_: 5tqh A: [329009]
        automated match to d1t0la_
        complexed with 7j2, flc, ndp; mutant
      2. 2513344Domain d5tqhb_: 5tqh B: [329108]
        automated match to d1t0la_
        complexed with 7j2, flc, ndp; mutant
      3. 2513345Domain d5tqhc_: 5tqh C: [329014]
        automated match to d1t0la_
        complexed with 7j2, flc, ndp; mutant
      4. 2513346Domain d5tqhd_: 5tqh D: [329032]
        automated match to d1t0la_
        complexed with 7j2, flc, ndp; mutant
    16. Domains for 5yfm:
      1. 2513365Domain d5yfma_: 5yfm A: [340721]
        automated match to d1t0la_
        complexed with mg, nap
      2. 2513366Domain d5yfmb_: 5yfm B: [340751]
        automated match to d1t0la_
        complexed with mg, nap
      3. 2513367Domain d5yfmc_: 5yfm C: [340807]
        automated match to d1t0la_
        complexed with mg, nap
    17. Domains for 5yfn:
      1. 2513372Domain d5yfna1: 5yfn A:1-411 [340740]
        Other proteins in same PDB: d5yfna2, d5yfnb2
        automated match to d1t0la_
        complexed with ict, k, mg
      2. 2513373Domain d5yfnb1: 5yfn B:1-412 [340752]
        Other proteins in same PDB: d5yfna2, d5yfnb2
        automated match to d1t0la_
        complexed with ict, k, mg
    18. Domains for 6b0z:
      1. 2513357Domain d6b0za_: 6b0z A: [341343]
        automated match to d1t0la_
        complexed with c81, flc, ndp; mutant
      2. 2513358Domain d6b0zb_: 6b0z B: [341187]
        automated match to d1t0la_
        complexed with c81, flc, ndp; mutant
      3. 2513359Domain d6b0zc_: 6b0z C: [341183]
        automated match to d1t0la_
        complexed with c81, flc, ndp; mutant
      4. 2513360Domain d6b0zd_: 6b0z D: [341180]
        automated match to d1t0la_
        complexed with c81, flc, ndp; mutant
    19. Domains for 6bkx:
      1. 2513300Domain d6bkxa1: 6bkx A:3-414 [355254]
        Other proteins in same PDB: d6bkxa2, d6bkxb2, d6bkxc2
        automated match to d1t0la_
        complexed with ca, dwp, ict
      2. 2513301Domain d6bkxb1: 6bkx B:3-414 [355192]
        Other proteins in same PDB: d6bkxa2, d6bkxb2, d6bkxc2
        automated match to d1t0la_
        complexed with ca, dwp, ict
      3. 2513302Domain d6bkxc1: 6bkx C:3-414 [355089]
        Other proteins in same PDB: d6bkxa2, d6bkxb2, d6bkxc2
        automated match to d1t0la_
        complexed with ca, dwp, ict
    20. Domains for 6bky:
      1. 2513330Domain d6bkya1: 6bky A:3-414 [355314]
        Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2
        automated match to d1t0la_
        complexed with k32, lmr, mg
      2. 2513331Domain d6bkyb1: 6bky B:3-414 [355346]
        Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2
        automated match to d1t0la_
        complexed with k32, lmr, mg
      3. 2513332Domain d6bkyc1: 6bky C:3-414 [355146]
        Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2
        automated match to d1t0la_
        complexed with k32, lmr, mg
      4. 2513333Domain d6bkyd1: 6bky D:3-414 [355264]
        Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2
        automated match to d1t0la_
        complexed with k32, lmr, mg
      5. 2513334Domain d6bkye1: 6bky E:3-414 [355364]
        Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2
        automated match to d1t0la_
        complexed with k32, lmr, mg
      6. 2513335Domain d6bkyf1: 6bky F:3-414 [355217]
        Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2
        automated match to d1t0la_
        complexed with k32, lmr, mg
    21. Domains for 6bkz:
      1. 2513313Domain d6bkza_: 6bkz A: [355090]
        automated match to d1t0la_
        complexed with dwm, nap
      2. 2513314Domain d6bkzb_: 6bkz B: [355305]
        automated match to d1t0la_
        complexed with dwm, nap
    22. Domains for 6bl0:
      1. 2513340Domain d6bl0a1: 6bl0 A:3-414 [355222]
        Other proteins in same PDB: d6bl0a2, d6bl0b2, d6bl0c2
        automated match to d1t0la_
        complexed with dwj, ict, mg, nap
      2. 2513341Domain d6bl0b1: 6bl0 B:3-414 [355091]
        Other proteins in same PDB: d6bl0a2, d6bl0b2, d6bl0c2
        automated match to d1t0la_
        complexed with dwj, ict, mg, nap
      3. 2513342Domain d6bl0c1: 6bl0 C:3-414 [355291]
        Other proteins in same PDB: d6bl0a2, d6bl0b2, d6bl0c2
        automated match to d1t0la_
        complexed with dwj, ict, mg, nap
    23. Domains for 6bl1:
      1. 2513315Domain d6bl1a1: 6bl1 A:3-414 [355357]
        Other proteins in same PDB: d6bl1a2, d6bl1b2, d6bl1c2
        automated match to d1t0la_
        complexed with ca, dwg, ict
      2. 2513316Domain d6bl1b1: 6bl1 B:3-414 [355353]
        Other proteins in same PDB: d6bl1a2, d6bl1b2, d6bl1c2
        automated match to d1t0la_
        complexed with ca, dwg, ict
      3. 2513317Domain d6bl1c1: 6bl1 C:3-414 [355184]
        Other proteins in same PDB: d6bl1a2, d6bl1b2, d6bl1c2
        automated match to d1t0la_
        complexed with ca, dwg, ict
    24. Domains for 6bl2:
      1. 2513310Domain d6bl2a1: 6bl2 A:3-414 [355327]
        Other proteins in same PDB: d6bl2a2, d6bl2b2, d6bl2c2
        automated match to d1t0la_
        complexed with ca, dws, ict
      2. 2513311Domain d6bl2b1: 6bl2 B:3-414 [355177]
        Other proteins in same PDB: d6bl2a2, d6bl2b2, d6bl2c2
        automated match to d1t0la_
        complexed with ca, dws, ict
      3. 2513312Domain d6bl2c1: 6bl2 C:3-414 [355092]
        Other proteins in same PDB: d6bl2a2, d6bl2b2, d6bl2c2
        automated match to d1t0la_
        complexed with ca, dws, ict
    25. Domains for 6io0:
      1. 2513349Domain d6io0a_: 6io0 A: [376199]
        automated match to d1t0la_
        complexed with aou, cit, gol, ndp; mutant
      2. 2513350Domain d6io0b_: 6io0 B: [376206]
        automated match to d1t0la_
        complexed with aou, cit, gol, ndp; mutant
    26. Domains for 6o2y:
      1. 2513384Domain d6o2ya1: 6o2y A:3-414 [370972]
        Other proteins in same PDB: d6o2ya2
        automated match to d1t0la_
        complexed with bme, ljy, nap; mutant
      2. 2513385Domain d6o2yb_: 6o2y B: [370969]
        Other proteins in same PDB: d6o2ya2
        automated match to d1t0la_
        complexed with bme, ljy, nap; mutant
      3. 2513386Domain d6o2yc_: 6o2y C: [370961]
        Other proteins in same PDB: d6o2ya2
        automated match to d1t0la_
        complexed with bme, ljy, nap; mutant
    27. Domains for 6o2z:
      1. 2513370Domain d6o2za1: 6o2z A:3-414 [371022]
        Other proteins in same PDB: d6o2za2, d6o2zb2
        automated match to d1t0la_
        complexed with gol, ljv, nap; mutant
      2. 2513371Domain d6o2zb1: 6o2z B:3-414 [370999]
        Other proteins in same PDB: d6o2za2, d6o2zb2
        automated match to d1t0la_
        complexed with gol, ljv, nap; mutant
    28. Domains for 6pay:
      1. 2513336Domain d6paya_: 6pay A: [374398]
        automated match to d1t0la_
        complexed with fmt, ict, mg, ndp
      2. 2513337Domain d6payb_: 6pay B: [374311]
        automated match to d1t0la_
        complexed with fmt, ict, mg, ndp
      3. 2513338Domain d6payc_: 6pay C: [374291]
        automated match to d1t0la_
        complexed with fmt, ict, mg, ndp
      4. 2513339Domain d6payd_: 6pay D: [374347]
        automated match to d1t0la_
        complexed with fmt, ict, mg, ndp
    29. Domains for 6u4j:
      1. 2513323Domain d6u4ja1: 6u4j A:3-414 [381955]
        Other proteins in same PDB: d6u4ja2
        automated match to d1t0la_
        complexed with cl, flc, nap, pwv; mutant
      2. 2513324Domain d6u4jb_: 6u4j B: [381913]
        Other proteins in same PDB: d6u4ja2
        automated match to d1t0la_
        complexed with cl, flc, nap, pwv; mutant
    30. Domains for 6vei:
      1. 2513321Domain d6veia1: 6vei A:3-414 [380285]
        Other proteins in same PDB: d6veia2, d6veib2
        automated match to d1t0la_
        complexed with 33o, 9uo, act, mla, mlt, ndp, peg, so4; mutant
      2. 2513322Domain d6veib1: 6vei B:3-414 [380265]
        Other proteins in same PDB: d6veia2, d6veib2
        automated match to d1t0la_
        complexed with 33o, 9uo, act, mla, mlt, ndp, peg, so4; mutant
    31. Domains for 6vg0:
      1. 2513374Domain d6vg0a_: 6vg0 A: [380306]
        Other proteins in same PDB: d6vg0b2
        automated match to d1t0la_
        complexed with ndp, qwm; mutant
      2. 2513375Domain d6vg0b1: 6vg0 B:2-414 [380273]
        Other proteins in same PDB: d6vg0b2
        automated match to d1t0la_
        complexed with ndp, qwm; mutant
      3. 2513376Domain d6vg0c_: 6vg0 C: [380257]
        Other proteins in same PDB: d6vg0b2
        automated match to d1t0la_
        complexed with ndp, qwm; mutant
  2. 2513394Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)
    1. Domains for 1j1w:
      1. 2513397Domain d1j1wa_: 1j1w A: [90772]
        complexed with nap
      2. 2513398Domain d1j1wb_: 1j1w B: [90773]
        complexed with nap
      3. 2513399Domain d1j1wc_: 1j1w C: [90774]
        complexed with nap
      4. 2513400Domain d1j1wd_: 1j1w D: [90775]
        complexed with nap
    2. Domains for 1lwd:
      1. 2513395Domain d1lwda_: 1lwd A: [78265]
        complexed with ict, mn, so4
      2. 2513396Domain d1lwdb_: 1lwd B: [78266]
        complexed with ict, mn, so4

More info for Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Timeline for Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases: