SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.43.1.3: Choline/Carnitine O-acyltransferase

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2115786Fold c.43: CoA-dependent acyltransferases [52776] (1 superfamily)
    core: 2 layers, a/b; mixed beta-sheet of 6 strands, order 324561; strands 3 & 6 are antiparallel to the rest
  4. 2115787Superfamily c.43.1: CoA-dependent acyltransferases [52777] (5 families) (S)
  5. 2115880Family c.43.1.3: Choline/Carnitine O-acyltransferase [82424] (3 protein domains)
    Pfam PF00755; monomeric enzyme containing tandem repeat of two CAT subunit-like domains

Protein Domains:

  1. 2115881Carnitine acetyltransferase [82425] (2 species)
    relative spatial position of the domains is similar to the monomers in CAT trimer
    1. 2115882Species Human (Homo sapiens) [TaxId:9606] [89697] (2 PDB entries)
    2. 2115887Species Mouse (Mus musculus) [TaxId:10090] [82426] (9 PDB entries)
      Uniprot P47934
  2. 2115920Choline O-acetyltransferase [110591] (2 species)
    1. 2115921Species Human (Homo sapiens) [TaxId:9606] [225187] (4 PDB entries)
    2. 2115930Species Norway rat (Rattus norvegicus) [TaxId:10116] [110592] (2 PDB entries)
      Uniprot P32738
  3. 2115937Peroxisomal carnitine O-octanoyltransferase, COT [117575] (1 species)

More info for Family c.43.1.3: Choline/Carnitine O-acyltransferase

Timeline for Family c.43.1.3: Choline/Carnitine O-acyltransferase: