SCOPe 2.08: Family c.43.1.3: Choline/Carnitine O-acyltransferase

Lineage for Family c.43.1.3: Choline/Carnitine O-acyltransferase

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.43: CoA-dependent acyltransferases [52776] (1 superfamily)
   core: 2 layers, a/b; mixed beta-sheet of 6 strands, order 324561; strands 3 & 6 are antiparallel to the rest

4. Superfamily c.43.1: CoA-dependent acyltransferases [52777] (5 families)

5. Family c.43.1.3: Choline/Carnitine O-acyltransferase [82424] (6 proteins)
   Pfam PF00755; monomeric enzyme containing tandem repeat of two CAT subunit-like domains

Proteins:

1. Carnitine acetyltransferase, C-terminal domain [418983] (2 species)
   relative spatial position of the domains is similar to the monomers in CAT trimer
   1. Species Human (Homo sapiens) [TaxId:9606] [419451] (2 PDB entries)
   2. Species Mouse (Mus musculus) [TaxId:10090] [419453] (9 PDB entries)
      Uniprot P47934

2. Carnitine acetyltransferase, N-terminal domain [418982] (2 species)
   relative spatial position of the domains is similar to the monomers in CAT trimer

   1. Species Human (Homo sapiens) [TaxId:9606] [419450] (2 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [419452] (9 PDB entries)
      Uniprot P47934

3. Choline O-acetyltransferase, C-terminal domain [418985] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [419455] (4 PDB entries)

   2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [419457] (2 PDB entries)
      Uniprot P32738

4. Choline O-acetyltransferase, N-terminal domain [418984] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [419454] (4 PDB entries)

   2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [419456] (2 PDB entries)
      Uniprot P32738

5. Peroxisomal carnitine O-octanoyltransferase, COT, C-terminal domain [418987] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [419459] (4 PDB entries)
     Uniprot Q9DC50

6. Peroxisomal carnitine O-octanoyltransferase, COT, N-terminal domain [418986] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [419458] (4 PDB entries)
     Uniprot Q9DC50

More info for Family c.43.1.3: Choline/Carnitine O-acyltransferase

Timeline for Family c.43.1.3: Choline/Carnitine O-acyltransferase:

• Family c.43.1.3: Choline/Carnitine O-acyltransferase first appeared in SCOP 1.63, called Family c.43.1.3: Carnitine acetyltransferase
  
• Family c.43.1.3: Choline/Carnitine O-acyltransferase appears in SCOPe 2.07