SCOPe 2.05: Family c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2)

Lineage for Family c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.108: HAD-like [56783] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456

4. Superfamily c.108.1: HAD-like [56784] (26 families)
   usually contains an insertion (sub)domain after strand 1

5. Family c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) [82382] (2 proteins)
   the insertion subdomain is a 4-helical bundle; dephosphorylates dUMP and dTMP
   automatically mapped to Pfam PF06941

Proteins:

1. 5'(3')-deoxyribonucleotidase (dNT-2) [82383] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [82384] (4 PDB entries)

2. automated matches [190171] (2 species)
   not a true protein

   1. Species Human (Homo sapiens) [TaxId:9606] [186899] (17 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [188278] (2 PDB entries)

More info for Family c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2)

Timeline for Family c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2):

• Family c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) first appeared in SCOP 1.63
  
• Family c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) appears in SCOPe 2.04
  
• Family c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) appears in SCOPe 2.06
  
• Family c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) appears in the current release, SCOPe 2.08