SCOPe 2.05: Family b.85.7.1: Histone lysine methyltransferases

Lineage for Family b.85.7.1: Histone lysine methyltransferases

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.85: beta-clip [51268] (7 superfamilies)
   double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll

4. Superfamily b.85.7: SET domain [82199] (4 families)
   duplication: the core is composed of two structural repeats similar to (circularly permuted) repeats of AFPIII
   also contains a substrate-binding alpha+beta subdomain inserted in the core

5. Family b.85.7.1: Histone lysine methyltransferases [82200] (3 proteins)
   contains metal-binding preSET and postSET domains

Proteins:

1. Dim-5 [82201] (1 species)

   • Species Fungus (Neurospora crassa) [TaxId:5141] [82202] (2 PDB entries)

2. Histone H3 K4-specific methyltransferase SET7/9 catalytic domain [82205] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [82206] (17 PDB entries)
     Uniprot Q8WTS6 52-336

3. SET domain of Clr4 [82203] (1 species)
   ortholog of Dim-5

   • Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82204] (2 PDB entries)

More info for Family b.85.7.1: Histone lysine methyltransferases

Timeline for Family b.85.7.1: Histone lysine methyltransferases:

• Family b.85.7.1: Histone lysine methyltransferases first appeared in SCOP 1.63
  
• Family b.85.7.1: Histone lysine methyltransferases appears in SCOPe 2.04
  
• Family b.85.7.1: Histone lysine methyltransferases appears in SCOPe 2.06
  
• Family b.85.7.1: Histone lysine methyltransferases appears in the current release, SCOPe 2.08