SCOPe 2.06: Protein: Hypoxia-inducible factor HIF ihhibitor (FIH1)

Lineage for Protein: Hypoxia-inducible factor HIF ihhibitor (FIH1)

Root: SCOPe 2.06
Class b: All beta proteins [48724] (177 folds)

Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
one turn of helix is made by two pairs of antiparallel strands linked with short turns
has appearance of a sandwich of distinct architecture and jelly-roll topology

Superfamily b.82.2: Clavaminate synthase-like [51197] (16 families)
Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold
Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) [82194] (1 protein)
Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) [82195] (1 species)

Species:

Human (Homo sapiens) [TaxId:9606] [82196] (34 PDB entries)
1. Domain for 1h2k:
  - Domain d1h2ka_: 1h2k A: [76572]
    Other proteins in same PDB: d1h2ks_
    complex with HIF-1 alpha fragment peptide
    complexed with fe2, oga, so4
2. Domain for 1h2l:
  - Domain d1h2la_: 1h2l A: [76574]
    Other proteins in same PDB: d1h2ls_
    complex with HIF-1 alpha fragment peptide
    complexed with akg, fe2, so4
3. Domain for 1h2m:
  - Domain d1h2ma_: 1h2m A: [76576]
    complex with HIF-1 alpha fragment peptide
    complexed with oga, so4, zn
4. Domain for 1h2n:
  - Domain d1h2na_: 1h2n A: [76577]
    complexed with akg, fe2, so4
5. Domain for 1iz3:
  - Domain d1iz3a_: 1iz3 A: [83831]
    complexed with so4
6. Domain for 1mze:
  - Domain d1mzea_: 1mze A: [79694]
    complexed with fe2, tar
7. Domain for 1mzf:
  - Domain d1mzfa_: 1mzf A: [79695]
    complexed with akg, fe2
8. Domain for 1yci:
  - Domain d1ycia_: 1yci A: [122965]
    automated match to d1iz3a_
    complexed with fe2, ndf, so4
9. Domain for 2cgn:
  - Domain d2cgna_: 2cgn A: [130426]
    automated match to d1iz3a_
    complexed with fe, sin, so4
10. Domain for 2cgo:
  - Domain d2cgoa_: 2cgo A: [130427]
    automated match to d1iz3a_
    complexed with fe, fum, so4
11. Domain for 2ilm:
  - Domain d2ilma_: 2ilm A: [165609]
    automated match to d1iz3a_
    complexed with akg, bct, fe2, gol, so4; mutant
12. Domain for 2w0x:
  - Domain d2w0xa_: 2w0x A: [168991]
    automated match to d1iz3a_
    complexed with fe2, gol, pd2, so4
13. Domain for 2wa3:
  - Domain d2wa3a_: 2wa3 A: [169158]
    automated match to d1iz3a_
    complexed with a29, fe2
14. Domain for 2wa4:
  - Domain d2wa4a_: 2wa4 A: [169159]
    automated match to d1iz3a_
    complexed with 069, fe2, so4
15. Domain for 2xum:
  - Domain d2xuma_: 2xum A: [170406]
    automated match to d1iz3a_
    complexed with oga, so4, zn; mutant
16. Domain for 2y0i:
  - Domain d2y0ia_: 2y0i A: [170508]
    automated match to d1iz3a_
    complexed with akg, fe2, gol, so4
17. Domain for 2yc0:
  - Domain d2yc0a_: 2yc0 A: [170733]
    automated match to d1iz3a_
    complexed with 2hg, fe2, gol, so4
18. Domain for 2yde:
  - Domain d2ydea_: 2yde A: [170762]
    automated match to d1iz3a_
    complexed with fe, gol, s2g, so4
19. Domain for 3d8c:
  - Domain d3d8ca1: 3d8c A:11-349 [173751]
    Other proteins in same PDB: d3d8ca2
    automated match to d1iz3a_
    complexed with akg, gol, so4, zn; mutant
20. Domain for 3kcx:
  - Domain d3kcxa_: 3kcx A: [179281]
    automated match to d1h2ka_
    complexed with cql, fe2, gol, so4
21. Domain for 3kcy:
  - Domain d3kcya_: 3kcy A: [179282]
    automated match to d1h2ka_
    complexed with fe2, hqy, so4
22. Domain for 3od4:
  - Domain d3od4a_: 3od4 A: [182942]
    automated match to d1iz3a_
    complexed with 8xq, gol, so4, zn
23. Domain for 3p3n:
  - Domain d3p3na_: 3p3n A: [183489]
    automated match to d1iz3a_
    complexed with akg, fe2, gol, so4
24. Domain for 3p3p:
  - Domain d3p3pa_: 3p3p A: [183490]
    automated match to d1iz3a_
    complexed with akg, fe2, gol, so4
25. Domain for 4ai8:
  - Domain d4ai8a_: 4ai8 A: [218892]
    automated match to d2y0ia_
    complexed with dza, gol, so4, zn
26. Domain for 4bio:
  - Domain d4bioa_: 4bio A: [196880]
    automated match to d2cgna_
    protein/DNA complex; complexed with 8xq, fe, gol, so4
27. Domain for 4nr1:
  - Domain d4nr1a_: 4nr1 A: [307789]
    automated match to d3p3na_
    protein/DNA complex; complexed with oga, so4, zn
28. Domain for 4z1v:
  - Domain d4z1va_: 4z1v A: [280551]
    automated match to d2xuma_
    complexed with fe, no, oga, peg, so4
29. Domain for 4z2w:
  - Domain d4z2wa_: 4z2w A: [280555]
    automated match to d2xuma_
    complexed with akg, fe, peg, so4
30. Domain for 5jwk:
  - Domain d5jwka_: 5jwk A: [334137]
    automated match to d3p3na_
    complexed with akg, fe2, peg, so4
31. Domain for 5jwl:
  - Domain d5jwla_: 5jwl A: [334110]
    automated match to d3p3na_
    complexed with akg, peg, so4, zn
32. Domain for 5op6:
  - Domain d5op6a_: 5op6 A: [340273]
    automated match to d3p3na_
    protein/DNA complex; complexed with a0w, gol, so4, zn
33. Domain for 5op8:
  - Domain d5op8a_: 5op8 A: [340272]
    automated match to d3p3na_
    protein/DNA complex; complexed with a1h, gol, so4, zn
34. Domain for 5opc:
  - Domain d5opca_: 5opc A: [340276]
    automated match to d3p3na_
    protein/DNA complex; complexed with a1z, gol, so4, zn

More info for Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) from b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1)

Timeline for Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) from b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1):

Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) from b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) first appeared in SCOP 1.63
Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) from b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) appears in SCOPe 2.05
Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) from b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) appears in SCOPe 2.07
Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) from b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) appears in the current release, SCOPe 2.08