SCOPe 2.06: Family f.21.2.2: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)

Lineage for Family f.21.2.2: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)

1. Root: SCOPe 2.06

2. Class f: Membrane and cell surface proteins and peptides [56835] (59 folds)

3. Fold f.21: Heme-binding four-helical bundle [81344] (3 superfamilies)
   core: four transmembrane helices, up-and-down bundle, binds one or two heme groups in between the helices

4. Superfamily f.21.2: Fumarate reductase respiratory complex transmembrane subunits [81343] (2 families)
   two distinct families: in one family the common fold is contained in a single-chain subunit, in the other it is formed by two chains

5. Family f.21.2.2: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) [81373] (7 proteins)
   consists of two homologous non-identical subunits that form a heterodimer; may or may not contain heme groups

Proteins:

1. Fumarate reductase subunit FrdC [81370] (2 species)

   1. Species Escherichia coli [TaxId:536056] [224948] (2 PDB entries)

   2. Species Escherichia coli [TaxId:562] [81369] (5 PDB entries)
      is not known to bind heme

2. Fumarate reductase subunit FrdD [81372] (2 species)

   1. Species Escherichia coli [TaxId:536056] [192449] (1 PDB entry)

   2. Species Escherichia coli [TaxId:562] [81371] (6 PDB entries)
      is not known to bind heme

3. Large cytochrome binding protein CybL [254390] (1 species)

   • Species Pig (Sus scrofa) [TaxId:9823] [254826] (5 PDB entries)

4. Small cytochrome binding protein CybS [254391] (1 species)
   Pfam PF05328; PubMed 15989954

   • Species Pig (Sus scrofa) [TaxId:9823] [254827] (5 PDB entries)

5. Succinate dehydrogenase subunit SdhC [82870] (1 species)
   Cytochrome b556 subunit

   • Species Escherichia coli [TaxId:562] [82871] (7 PDB entries)

6. Succinate dehydrogenase subunit SdhD [82872] (1 species)
   membrane anchor protein

   • Species Escherichia coli [TaxId:562] [82873] (6 PDB entries)

7. automated matches [254461] (3 species)
   not a true protein

   1. Species Chicken (Gallus gallus) [TaxId:9031] [254987] (6 PDB entries)

   2. Species Escherichia coli [TaxId:701177] [256012] (2 PDB entries)

   3. Species Pig (Sus scrofa) [TaxId:9823] [255743] (5 PDB entries)

More info for Family f.21.2.2: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)

Timeline for Family f.21.2.2: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD):

• Family f.21.2.2: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) first appeared in SCOP 1.63
  
• Family f.21.2.2: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) appears in SCOPe 2.05
  
• Family f.21.2.2: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) appears in SCOPe 2.07
  
• Family f.21.2.2: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) appears in the current release, SCOPe 2.08