SCOPe 2.05: Family a.77.1.2: DEATH domain, DD

Lineage for Family a.77.1.2: DEATH domain, DD

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.77: DEATH domain [47985] (1 superfamily)
   6 helices: closed bundle; greek-key; internal pseudo twofold symmetry

4. Superfamily a.77.1: DEATH domain [47986] (5 families)

5. Family a.77.1.2: DEATH domain, DD [81312] (9 proteins)
   Pfam PF00531

Proteins:

1. FADD (Mort1) [47992] (2 species)
   contains two domains of this superfamily: DED and DD, in this order

   1. Species Human (Homo sapiens) [TaxId:9606] [47993] (4 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [47994] (1 PDB entry)

2. Fas [47990] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47991] (1 PDB entry)

3. Interleukin-1 receptor-associated kinase 4, IRAK4 [116951] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [116952] (1 PDB entry)
     Uniprot Q8R4K2 1-114

4. Netrin receptor UNC5B [116953] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [116954] (1 PDB entry)
     Uniprot Q8K1S3 854-943

5. p75 low affinity neurotrophin receptor [47988] (1 species)
   residues 334-418

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [47989] (1 PDB entry)

6. Pelle death domain [48003] (1 species)

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [48004] (3 PDB entries)

7. Tube death domain [48005] (1 species)
   complexed with Pelle death domain

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [48006] (1 PDB entry)

8. Tumor necrosis factor receptor-1 death domain [74741] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [74742] (1 PDB entry)

9. automated matches [190466] (3 species)
   not a true protein

   1. Species Human (Homo sapiens) [TaxId:9606] [188706] (4 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [187386] (1 PDB entry)

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [193052] (2 PDB entries)

More info for Family a.77.1.2: DEATH domain, DD

Timeline for Family a.77.1.2: DEATH domain, DD:

• Family a.77.1.2: DEATH domain, DD first appeared in SCOP 1.63
  
• Family a.77.1.2: DEATH domain, DD appears in SCOPe 2.04
  
• Family a.77.1.2: DEATH domain, DD appears in SCOPe 2.06
  
• Family a.77.1.2: DEATH domain, DD appears in the current release, SCOPe 2.08