Lineage for Superfamily d.218.1: Nucleotidyltransferase

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2563564Fold d.218: Nucleotidyltransferase [81302] (1 superfamily)
    core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123
  4. 2563565Superfamily d.218.1: Nucleotidyltransferase [81301] (16 families) (S)

Families:

  1. 2563566d.218.1.1: Kanamycin nucleotidyltransferase (KNTase), N-terminal domain [56708] (1 protein)
    insert X in the core is a beta-strand ; mixed 4-stranded sheet, order: 1243
  2. 2563573d.218.1.2: DNA polymerase beta-like [81300] (5 proteins)
    insert X in the core is an alpha-beta(2) unit; mixed 5-stranded sheet, order: 12543; contains extra C-terminal alpha+beta subdomain
  3. 2563854d.218.1.3: Poly(A) polymerase, PAP, N-terminal domain [81589] (1 protein)
    insert X in the core is an alpha-beta(2) unit; mixed 5-stranded sheet, order: 12543
  4. 2563869d.218.1.4: Poly A polymerase head domain-like [82661] (2 proteins)
    overlaps with the N-terminal part of Pfam PF01743; this family is distinct from eukaryotic PAPs
    insert X in the core is an alpha-beta(2) unit; contains two extra C-terminal strands; mixed 7-stranded sheet, order: 7612543
  5. 2563885d.218.1.5: Catalytic subunit of bi-partite nucleotidyltransferase [102932] (4 proteins)
    insert X in the core is an alpha-helix; minimal nucleotidyltransferase fold
    automatically mapped to Pfam PF01909
  6. 2563900d.218.1.6: 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain [102937] (1 protein)
    similar overall structure to the first two domains of poly(A) polymerase, PAP
  7. 2563909d.218.1.7: Archaeal tRNA CCA-adding enzyme catalytic domain [102940] (1 protein)
    similar overall structure to poly(A) polymerase, PAP
  8. 2563945d.218.1.8: RelA/SpoT domain [102945] (3 proteins)
    Pfam PF04607; ppGpp-synthetase
  9. 2563984d.218.1.9: GlnE-like domain [110933] (1 protein)
    Pfam PF03710; Pfam coverage excludes the extra N-terminal subdomain but includes a short segment of the next domain 2
  10. 2563988d.218.1.10: RNA editing terminal uridyl transferase 2, RET2, catalytic domain [143236] (1 protein)
    contains insert domain of a ferredoxin-like fold
  11. 2563994d.218.1.11: TM1012-like [143239] (2 proteins)
    insert X in the core is an alpha-beta(2) unit; contains extra C-terminal structures; mixed 7-stranded sheet, order: 6712543;
  12. 2564002d.218.1.12: Iojap/YbeB-like [160252] (2 proteins)
    Pfam PF02410, probably has evolved a different function; closer relationship to the GrpB-like family
  13. 2564011d.218.1.13: AadK N-terminal domain-like [160257] (1 protein)
    N-terminal part of Pfam PF04439; Streptomycin adenylyltransferase; insert X is alpha-beta(2) unit; overall domain architecture is similar to Kanamycin nucleotidyltransferase
  14. 2564015d.218.1.14: GrpB-like [160260] (1 protein)
    Pfam PF04229, different set of active-site residues
  15. 2564019d.218.1.15: cGAMP synthase, cGAS N-terminal domain [254174] (1 protein)
    Pfam PF03281; PubMed 23647843; structurally very similar to hOAS1 (d.218.1.6)
  16. 2564030d.218.1.0: automated matches [227287] (1 protein)
    not a true family

More info for Superfamily d.218.1: Nucleotidyltransferase

Timeline for Superfamily d.218.1: Nucleotidyltransferase: