SCOPe 2.05: Family b.1.18.7: ML domain

Lineage for Family b.1.18.7: ML domain

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.18: E set domains [81296] (24 families)
   "Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies

5. Family b.1.18.7: ML domain [81287] (2 proteins)
   implicated in lipid recognition, particularly in the recognition of pathogen related products
   automatically mapped to Pfam PF02221

Proteins:

1. Epididymal secretory protein E1 (Niemann-Pick C2 protein) [81964] (1 species)
   a cholesterol binding protein

   • Species Cow (Bos taurus) [TaxId:9913] [81965] (2 PDB entries)

2. Major mite allergen [49256] (2 species)
   contains additional N-terminal strand

   1. Species House-dust mite (Dermatophagoides farinae), Der f 2 [TaxId:6954] [49257] (5 PDB entries)
      Uniprot Q00855 18-146

   2. Species House-dust mite (Dermatophagoides pteronyssinus), Der p 2 [TaxId:6956] [49258] (2 PDB entries)

More info for Family b.1.18.7: ML domain

Timeline for Family b.1.18.7: ML domain:

• Family b.1.18.7: ML domain first appeared in SCOP 1.63
  
• Family b.1.18.7: ML domain appears in SCOPe 2.04
  
• Family b.1.18.7: ML domain appears in SCOPe 2.06
  
• Family b.1.18.7: ML domain appears in the current release, SCOPe 2.08