Lineage for Family c.37.1.19: Tandem AAA-ATPase domain

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 695085Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 695086Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (24 families) (S)
    division into families based on beta-sheet topologies
  5. 697477Family c.37.1.19: Tandem AAA-ATPase domain [81268] (22 proteins)
    duplication: tandem repeat of two RecA-like (AAA) domains

Proteins:

  1. 697478ATP-dependent RNA helicase DDX25 [142310] (1 species)
  2. 697484DEAD box RNA helicase rck/p54 [102387] (1 species)
  3. 697488DEXX box DNA helicase [52701] (2 species)
    each AAA domain contains an all-alpha insert subdomain
    1. 697489Species Bacillus stearothermophilus, PcrA [TaxId:1422] [52702] (5 PDB entries)
    2. 697501Species Escherichia coli, RepD [TaxId:562] [52703] (1 PDB entry)
  4. 697506DNA repair protein RAD25 [142318] (1 species)
    shares with the DNA helicase UvsW (scop_fa 102396) extra N-terminal alpha+beta subdomain that might be related to the DNA repair protein MutS domain I (scop_sf 55271)
  5. 697518Exodeoxyribonuclease V alpha chain (RecD) [117554] (1 species)
    contains extra N-terminal alpha+beta (sub)domain (~100 residues)
  6. 697524Exodeoxyribonuclease V beta chain (RecB), N-terminal domain [117550] (1 species)
    each AAA domain contains an all-alpha insert subdomain
  7. 697530Exodeoxyribonuclease V gamma chain (RecC), N-terminal domain [117552] (1 species)
    each AAA domain contains an all-alpha insert subdomain
  8. 697536Helicase of the SNF2/Rad54 hamily [142312] (1 species)
  9. 697546Initiation factor 4a [52706] (2 species)
    homologous to UvrB
    1. 697547Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52707] (4 PDB entries)
    2. 697554Species Human (Homo sapiens) [TaxId:9606] [142305] (1 PDB entry)
      4A-I
  10. 697557Nucleotide excision repair enzyme UvrB [52708] (2 species)
    contains large insertions in the first AAA domain
    1. 697558Species Bacillus caldotenax [TaxId:1395] [52710] (4 PDB entries)
    2. 697571Species Thermus thermophilus [TaxId:274] [52709] (2 PDB entries)
  11. 697576Probable ATP-dependent RNA helicase DDX48 [142314] (1 species)
    Eukaryotic translation initiation factor 4A isoform 3
  12. 697588Probable DEAD box RNA helicase YqfR [102383] (1 species)
  13. 697592Putative ATP-dependent RNA helicase DHH1 [142322] (1 species)
  14. 697596putative ATP-dependent RNA helicase PF2015 [142308] (1 species)
    separate structures of other domains are known: the middle nuclease domain (scop_sp 89718) and the C-terminal RuvA-like HhH domain (PDB 1x2i)
  15. 697600putative ATP-dependent RNA helicase VlgB [142306] (1 species)
  16. 697604Putative DEAD box RNA helicase [52704] (1 species)
    homologous to eIF4a and UvrB
  17. 697610Rad54-like, Rad54L [142316] (1 species)
  18. 697614RecG helicase domain [69494] (1 species)
  19. 697618RecQ helicase domain [102385] (1 species)
  20. 697624Spliceosome RNA helicase BAT1 (UAP56) [110562] (1 species)
  21. 697635Transcription-repair coupling factor, TRCF [142320] (1 species)
    similar to UvrB in the N-terminal part and DEAD helicases in the C-terminal part; also contains CarD-like domain in the middle and TRCF domain at the C-terminus
  22. 697647Translocation ATPase SecA, nucleotide-binding domains [82414] (2 species)
    a pre-protein crosslinking domain inserted in the first AAA domain
    1. 697648Species Bacillus subtilis [TaxId:1423] [82415] (4 PDB entries)
    2. 697657Species Mycobacterium tuberculosis [TaxId:1773] [89687] (2 PDB entries)

More info for Family c.37.1.19: Tandem AAA-ATPase domain

Timeline for Family c.37.1.19: Tandem AAA-ATPase domain: