![]() | Class c: Alpha and beta proteins (a/b) [51349] (141 folds) |
![]() | Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily) 3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes |
![]() | Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (24 families) ![]() division into families based on beta-sheet topologies |
![]() | Family c.37.1.19: Tandem AAA-ATPase domain [81268] (22 proteins) duplication: tandem repeat of two RecA-like (AAA) domains |
![]() | ATP-dependent RNA helicase DDX25 [142310] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [142311] (1 PDB entry) |
![]() | DEAD box RNA helicase rck/p54 [102387] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [102388] (1 PDB entry) |
![]() | DEXX box DNA helicase [52701] (2 species) each AAA domain contains an all-alpha insert subdomain |
![]() | Species Bacillus stearothermophilus, PcrA [TaxId:1422] [52702] (5 PDB entries) |
![]() | Species Escherichia coli, RepD [TaxId:562] [52703] (1 PDB entry) |
![]() | DNA repair protein RAD25 [142318] (1 species) shares with the DNA helicase UvsW (scop_fa 102396) extra N-terminal alpha+beta subdomain that might be related to the DNA repair protein MutS domain I (scop_sf 55271) |
![]() | Species Archaeoglobus fulgidus [TaxId:2234] [142319] (3 PDB entries) |
![]() | Exodeoxyribonuclease V alpha chain (RecD) [117554] (1 species) contains extra N-terminal alpha+beta (sub)domain (~100 residues) |
![]() | Species Escherichia coli [TaxId:562] [117555] (1 PDB entry) |
![]() | Exodeoxyribonuclease V beta chain (RecB), N-terminal domain [117550] (1 species) each AAA domain contains an all-alpha insert subdomain |
![]() | Species Escherichia coli [TaxId:562] [117551] (1 PDB entry) |
![]() | Exodeoxyribonuclease V gamma chain (RecC), N-terminal domain [117552] (1 species) each AAA domain contains an all-alpha insert subdomain |
![]() | Species Escherichia coli [TaxId:562] [117553] (1 PDB entry) |
![]() | Helicase of the SNF2/Rad54 hamily [142312] (1 species) |
![]() | Species Sulfolobus solfataricus [TaxId:2287] [142313] (3 PDB entries) |
![]() | Initiation factor 4a [52706] (2 species) homologous to UvrB |
![]() | Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52707] (4 PDB entries) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [142305] (1 PDB entry) 4A-I |
![]() | Nucleotide excision repair enzyme UvrB [52708] (2 species) contains large insertions in the first AAA domain |
![]() | Species Bacillus caldotenax [TaxId:1395] [52710] (4 PDB entries) |
![]() | Species Thermus thermophilus [TaxId:274] [52709] (2 PDB entries) |
![]() | Probable ATP-dependent RNA helicase DDX48 [142314] (1 species) Eukaryotic translation initiation factor 4A isoform 3 |
![]() | Species Human (Homo sapiens) [TaxId:9606] [142315] (3 PDB entries) |
![]() | Probable DEAD box RNA helicase YqfR [102383] (1 species) |
![]() | Species Bacillus stearothermophilus [TaxId:1422] [102384] (1 PDB entry) |
![]() | Putative ATP-dependent RNA helicase DHH1 [142322] (1 species) |
![]() | Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [142323] (1 PDB entry) |
![]() | putative ATP-dependent RNA helicase PF2015 [142308] (1 species) separate structures of other domains are known: the middle nuclease domain (scop_sp 89718) and the C-terminal RuvA-like HhH domain (PDB 1x2i) |
![]() | Species Pyrococcus furiosus [TaxId:2261] [142309] (1 PDB entry) |
![]() | putative ATP-dependent RNA helicase VlgB [142306] (1 species) |
![]() | Species Flatworm (Dugesia japonica) [TaxId:6161] [142307] (1 PDB entry) |
![]() | Putative DEAD box RNA helicase [52704] (1 species) homologous to eIF4a and UvrB |
![]() | Species Archaeon Methanococcus jannaschii [TaxId:2190] [52705] (1 PDB entry) |
![]() | Rad54-like, Rad54L [142316] (1 species) |
![]() | Species Zebra fish (Danio rerio) [TaxId:7955] [142317] (1 PDB entry) |
![]() | RecG helicase domain [69494] (1 species) |
![]() | Species Thermotoga maritima [TaxId:2336] [69495] (1 PDB entry) |
![]() | RecQ helicase domain [102385] (1 species) |
![]() | Species Escherichia coli [TaxId:562] [102386] (2 PDB entries) |
![]() | Spliceosome RNA helicase BAT1 (UAP56) [110562] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [110563] (5 PDB entries) |
![]() | Transcription-repair coupling factor, TRCF [142320] (1 species) similar to UvrB in the N-terminal part and DEAD helicases in the C-terminal part; also contains CarD-like domain in the middle and TRCF domain at the C-terminus |
![]() | Species Escherichia coli [TaxId:562] [142321] (2 PDB entries) |
![]() | Translocation ATPase SecA, nucleotide-binding domains [82414] (2 species) a pre-protein crosslinking domain inserted in the first AAA domain |
![]() | Species Bacillus subtilis [TaxId:1423] [82415] (4 PDB entries) |
![]() | Species Mycobacterium tuberculosis [TaxId:1773] [89687] (2 PDB entries) |
Timeline for Family c.37.1.19: Tandem AAA-ATPase domain: