SCOP 1.69: Family c.37.1.19: Tandem AAA-ATPase domain

Lineage for Family c.37.1.19: Tandem AAA-ATPase domain

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (22 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.19: Tandem AAA-ATPase domain [81268] (10 proteins)
   duplication: tandem repeat of two RecA-like (AAA) domains

Proteins:

1. DEAD box RNA helicase rck/p54 [102387] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [102388] (1 PDB entry)

2. DEXX box DNA helicase [52701] (2 species)
   each AAA domain contains an all-alpha insert subdomain

   1. Species Bacillus stearothermophilus, PcrA [TaxId:1422] [52702] (5 PDB entries)

   2. Species Escherichia coli, RepD [TaxId:562] [52703] (1 PDB entry)

3. Initiation factor 4a [52706] (1 species)
   homologous to UvrB

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52707] (4 PDB entries)

4. Nucleotide excision repair enzyme UvrB [52708] (2 species)
   contains large insertions in the first AAA domain

   1. Species Bacillus caldotenax [TaxId:1395] [52710] (3 PDB entries)

   2. Species Thermus thermophilus [TaxId:274] [52709] (2 PDB entries)

5. Probable DEAD box RNA helicase YqfR [102383] (1 species)

   • Species Bacillus stearothermophilus [TaxId:1422] [102384] (1 PDB entry)

6. Putative DEAD box RNA helicase [52704] (1 species)
   homologous to eIF4a and UrvB

   • Species Archaeon Methanococcus jannaschii [TaxId:2190] [52705] (1 PDB entry)

7. RecG helicase domain [69494] (1 species)

   • Species Thermotoga maritima [TaxId:243274] [69495] (1 PDB entry)

8. RecQ helicase domain [102385] (1 species)

   • Species Escherichia coli [TaxId:562] [102386] (2 PDB entries)

9. Spliceosome RNA helicase BAT1 (UAP56) [110562] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [110563] (2 PDB entries)

10. Translocation ATPase SecA, nucleotide-binding domains [82414] (2 species)
    a pre-protein crosslinking domain inserted in the first AAA domain

    1. Species Bacillus subtilis [TaxId:1423] [82415] (4 PDB entries)

    2. Species Mycobacterium tuberculosis [TaxId:1773] [89687] (2 PDB entries)

More info for Family c.37.1.19: Tandem AAA-ATPase domain

Timeline for Family c.37.1.19: Tandem AAA-ATPase domain:

• Family c.37.1.19: Tandem AAA-ATPase domain first appeared in SCOP 1.63
  
• Family c.37.1.19: Tandem AAA-ATPase domain appears in SCOP 1.67
  
• Family c.37.1.19: Tandem AAA-ATPase domain appears in SCOP 1.71
  
• Family c.37.1.19: Tandem AAA-ATPase domain appears in the current release, SCOPe 2.08