Lineage for Family c.37.1.19: Tandem AAA-ATPase domain

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2446887Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2446888Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families) (S)
    division into families based on beta-sheet topologies
  5. 2451114Family c.37.1.19: Tandem AAA-ATPase domain [81268] (27 protein domains)
    duplication: tandem repeat of two RecA-like (AAA) domains

Protein Domains:

  1. 2451115ATP-dependent RNA helicase DDX25 [142310] (1 species)
  2. 2451119DEAD box RNA helicase rck/p54 [102387] (1 species)
  3. 2451123DEXX box DNA helicase [52701] (2 species)
    each AAA domain contains an all-alpha insert subdomain
    1. 2451124Species Bacillus stearothermophilus, PcrA [TaxId:1422] [52702] (5 PDB entries)
    2. 2451136Species Escherichia coli, RepD [TaxId:562] [52703] (1 PDB entry)
  4. 2451141DNA repair protein RAD25 [142318] (1 species)
    shares with the DNA helicase UvsW (102396) extra N-terminal alpha+beta subdomain that might be related to the DNA repair protein MutS domain I (55271)
  5. 2451153Exodeoxyribonuclease V alpha chain (RecD) [117554] (1 species)
    contains extra N-terminal alpha+beta (sub)domain (~100 residues)
  6. 2451159Exodeoxyribonuclease V beta chain (RecB), N-terminal domain [117550] (1 species)
    each AAA domain contains an all-alpha insert subdomain
  7. 2451165Exodeoxyribonuclease V gamma chain (RecC), N-terminal domain [117552] (1 species)
    each AAA domain contains an all-alpha insert subdomain
  8. 2451171Hel308 helicase [159575] (1 species)
  9. 2451175Helicase of the SNF2/Rad54 hamily [142312] (1 species)
  10. 2451181Initiation factor 4a [52706] (2 species)
    homologous to UvrB
    1. 2451182Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52707] (4 PDB entries)
    2. 2451189Species Human (Homo sapiens) [TaxId:9606] [142305] (2 PDB entries)
      Uniprot P60842 21-238
      4A-I
  11. 2451200Nucleotide excision repair enzyme UvrB [52708] (2 species)
    contains large insertions in the first AAA domain
    1. 2451201Species Bacillus caldotenax [TaxId:1395] [52710] (4 PDB entries)
      Uniprot P56981
    2. 2451214Species Thermus thermophilus [TaxId:274] [52709] (2 PDB entries)
  12. 2451219Pre-mRNA splicing factor Cwf11 / Aquarius [346069] (2 species)
    first domain includes 'stalk' (C-terminal part of Pfam PF16399), 'thumb' and 'pointer' insert subdomains described in PubMed 25599396
    1. 2451220Species Human (Homo sapiens) [TaxId:9606] [346287] (1 PDB entry)
    2. 2451223Species Schizosaccharomyces pombe 972h- [TaxId:284812] [346288] (1 PDB entry)
  13. 2451226Pre-mRNA splicing factor DEAH RNA helicase Prp43 [346070] (1 species)
    first domain contains extended N-terminal (sub)domain described in PubMed 20168331
  14. 2451236Probable ATP-dependent RNA helicase DDX48 [142314] (1 species)
    Eukaryotic translation initiation factor 4A isoform 3
  15. 2451246Probable DEAD box RNA helicase YqfR [102383] (1 species)
  16. 2451250Putative ATP-dependent RNA helicase DHH1 [142322] (1 species)
  17. 2451254putative ATP-dependent RNA helicase PF2015 [142308] (1 species)
    separate structures of other domains are known: the middle nuclease domain (89718) and the C-terminal RuvA-like HhH domain (PDB 1x2i)
  18. 2451268putative ATP-dependent RNA helicase VlgB [142306] (1 species)
  19. 2451271Putative DEAD box RNA helicase [52704] (1 species)
    homologous to eIF4a and UvrB
  20. 2451277Rad54-like, Rad54L [142316] (1 species)
  21. 2451281RecG helicase domain [69494] (1 species)
  22. 2451285RecQ helicase domain [102385] (1 species)
  23. 2451291Spliceosome RNA helicase BAT1 (UAP56) [110562] (1 species)
  24. 2451302Transcription-repair coupling factor, TRCF [142320] (1 species)
    similar to UvrB in the N-terminal part and DEAD helicases in the C-terminal part; also contains CarD-like domain in the middle and TRCF domain at the C-terminus
  25. 2451314Translocation ATPase SecA, nucleotide-binding domains [82414] (3 species)
    a pre-protein crosslinking domain inserted in the first AAA domain
    1. 2451315Species Bacillus subtilis [TaxId:1423] [82415] (4 PDB entries)
      Uniprot P28366
    2. 2451324Species Mycobacterium tuberculosis [TaxId:1773] [89687] (2 PDB entries)
    3. 2451333Species Thermotoga maritima MSB8 [TaxId:243274] [267718] (1 PDB entry)
  26. 2451338Upf1 [346071] (1 species)
    first domain includes small helical insert subdomain
  27. 2451348automated matches [190301] (5 species)
    not a true protein
    1. 2451349Species Escherichia coli K-12 [TaxId:83333] [232480] (1 PDB entry)
    2. 2451352Species Flatworm (Dugesia japonica) [TaxId:6161] [188089] (1 PDB entry)
    3. 2451354Species Human (Homo sapiens) [TaxId:9606] [187108] (3 PDB entries)
    4. Species Sulfolobus solfataricus [TaxId:2287] [267762] (1 PDB entry)
    5. 2451363Species Sulfolobus solfataricus [TaxId:273057] [267761] (1 PDB entry)

More info for Family c.37.1.19: Tandem AAA-ATPase domain

Timeline for Family c.37.1.19: Tandem AAA-ATPase domain: