SCOPe 2.01: Domain d1nlja_: 1nlj A:

Lineage for d1nlja_ (1nlj A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (26 proteins)

6. Protein (Pro)cathepsin K [54028] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [54029] (31 PDB entries)
   Uniprot P43235 116-329 ! Uniprot P43235 115-329

8. Domain d1nlja_: 1nlj A: [80626]
   complexed with 2ca

Details for d1nlja_

PDB Entry: 1nlj, 2.4 Å

PDB Description: crystal structure of the cysteine protease human cathepsin k in complex with a covalent azepanone inhibitor

PDB Compounds: (A:) cathepsin k

SCOPe Domain Sequences for d1nlja_:

Sequence; same for both SEQRES and ATOM records:

>d1nlja_ d.3.1.1 (A:) (Pro)cathepsin K {Human (Homo sapiens) [TaxId: 9606]}
apdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsen
dgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegneka
lkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwii
knswgenwgnkgyilmarnknnacgianlasfpkm

Timeline for d1nlja_:

• d1nlja_ first appeared in SCOP 1.63
  
• d1nlja_ appears in SCOP 1.75
  
• d1nlja_ appears in SCOPe 2.02
  
• d1nlja_ appears in the current release, SCOPe 2.08