SCOPe 2.03: Domain d1nbpa_: 1nbp A:

Lineage for d1nbpa_ (1nbp A:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Interleukin-2 (IL-2) [47301] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47302] (15 PDB entries)

8. Domain d1nbpa_: 1nbp A: [80392]
   complexed with mhc, so4

Details for d1nbpa_

PDB Entry: 1nbp, 2.2 Å

PDB Description: crystal structure of human interleukin-2 y31c covalently modified at c31 with 3-mercapto-1-(1,3,4,9-tetrahydro-b-carbolin-2-yl)-propan-1- one

PDB Compounds: (A:) interleukin-2

SCOPe Domain Sequences for d1nbpa_:

Sequence, based on SEQRES records:

>d1nbpa_ a.26.1.2 (A:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
stkktqlqlehllldlqmilnginncknpkltrmltfkfympkkatelkhlqcleeelkp
leevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnrwitfc
qsiistlt

Sequence, based on observed residues (ATOM records):

>d1nbpa_ a.26.1.2 (A:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
stkktqlqlehllldlqmilnginncknpkltrmltfkfympkkatelkhlqcleeelkp
leevlnlaqfhlrprdlisninvivlelkgfmceyadetativeflnrwitfcqsiistl
t

Timeline for d1nbpa_:

• d1nbpa_ first appeared in SCOP 1.63
  
• d1nbpa_ appears in SCOPe 2.02
  
• d1nbpa_ appears in SCOPe 2.04
  
• d1nbpa_ appears in the current release, SCOPe 2.08