Lineage for d1n8zb2 (1n8z B:121-220)

  1. Root: SCOP 1.71
  2. 546417Class b: All beta proteins [48724] (149 folds)
  3. 546418Fold b.1: Immunoglobulin-like beta-sandwich [48725] (25 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 546419Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 548299Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (23 proteins)
  6. 549023Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (5 species)
  7. 549027Species Human (Homo sapiens) [TaxId:9606] [88575] (105 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
  8. 549120Domain d1n8zb2: 1n8z B:121-220 [80321]
    Other proteins in same PDB: d1n8za1, d1n8za2, d1n8zb1, d1n8zc1, d1n8zc2, d1n8zc3, d1n8zc4
    part of humanized Fab 4D5, herceptin
    complexed with nag, so4

Details for d1n8zb2

PDB Entry: 1n8z (more details), 2.52 Å

PDB Description: Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab

SCOP Domain Sequences for d1n8zb2:

Sequence; same for both SEQRES and ATOM records: (download)

>d1n8zb2 b.1.1.2 (B:121-220) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens)}
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

SCOP Domain Coordinates for d1n8zb2:

Click to download the PDB-style file with coordinates for d1n8zb2.
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Timeline for d1n8zb2: