Lineage for d1n8zb1 (1n8z B:1-120)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2017117Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 protein domains)
  6. 2017323Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 2017327Species Engineered (including hybrid species) [88562] (68 PDB entries)
    SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody
  8. 2017412Domain d1n8zb1: 1n8z B:1-120 [80320]
    Other proteins in same PDB: d1n8za1, d1n8za2, d1n8zb2, d1n8zc1, d1n8zc2, d1n8zc3, d1n8zc4
    part of humanized Fab 4D5, herceptin
    complexed with nag, so4

Details for d1n8zb1

PDB Entry: 1n8z (more details), 2.52 Å

PDB Description: Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab
PDB Compounds: (B:) Herceptin Fab (antibody) - heavy chain

SCOPe Domain Sequences for d1n8zb1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1n8zb1 b.1.1.1 (B:1-120) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)}

SCOPe Domain Coordinates for d1n8zb1:

Click to download the PDB-style file with coordinates for d1n8zb1.
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Timeline for d1n8zb1: