SCOP 1.69: Domain d1n8za2: 1n8z A:108-214

Lineage for d1n8za2 (1n8z A:108-214)

1. Root: SCOP 1.69

2. Class b: All beta proteins [48724] (144 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (23 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (23 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (78 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)

8. Domain d1n8za2: 1n8z A:108-214 [80319]
   Other proteins in same PDB: d1n8za1, d1n8zb1, d1n8zb2, d1n8zc1, d1n8zc2, d1n8zc3, d1n8zc4
   part of humanized Fab 4D5, herceptin

Details for d1n8za2

PDB Entry: 1n8z, 2.52 Å

PDB Description: crystal structure of extracellular domain of human her2 complexed with herceptin fab

SCOP Domain Sequences for d1n8za2:

Sequence; same for both SEQRES and ATOM records:

>d1n8za2 b.1.1.2 (A:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens)}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1n8za2:

• d1n8za2 first appeared in SCOP 1.63
  
• d1n8za2 appears in SCOP 1.67
  
• d1n8za2 appears in SCOP 1.71
  
• d1n8za2 appears in the current release, SCOPe 2.08