SCOPe 2.08: Domain d1n7hb_: 1n7h B:

Lineage for d1n7hb_ (1n7h B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein GDP-mannose 4,6-dehydratase [51759] (4 species)

7. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)

8. Domain d1n7hb_: 1n7h B: [80251]
   complexed with gdp, ndp
   has additional subdomain(s) that are not in the common domain

Details for d1n7hb_

PDB Entry: 1n7h, 1.8 Å

PDB Description: Crystal Structure of GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDP

PDB Compounds: (B:) GDP-D-mannose-4,6-dehydratase

SCOPe Domain Sequences for d1n7hb_:

Sequence, based on SEQRES records:

>d1n7hb_ c.2.1.2 (B:) GDP-mannose 4,6-dehydratase {Thale cress (Arabidopsis thaliana) [TaxId: 3702]}
rkialitgitgqdgsyltefllgkgyevhglirrssnfntqrinhiyidphnvnkalmkl
hyadltdasslrrwidvikpdevynlaaqshvavsfeipdytadvvatgalrlleavrsh
tidsgrtvkyyqagssemfgstpppqsettpfhprspyaaskcaahwytvnyreayglfa
cngilfnhesprrgenfvtrkitralgrikvglqtklflgnlqasrdwgfagdyveamwl
mlqqekpddyvvateeghtveefldvsfgylglnwkdyveidqryfrpaevdnlqgdask
akevlgwkpqvgfeklvkmmvdedlelakrekvlvdagym

Sequence, based on observed residues (ATOM records):

>d1n7hb_ c.2.1.2 (B:) GDP-mannose 4,6-dehydratase {Thale cress (Arabidopsis thaliana) [TaxId: 3702]}
rkialitgitgqdgsyltefllgkgyevhglirrssnfntqrinhiyikalmklhyadlt
dasslrrwidvikpdevynlaaqshvavsfeipdytadvvatgalrlleavrshtidsgr
tvkyyqagssemfgstpppqsettpfhprspyaaskcaahwytvnyreayglfacngilf
nhesprrgenfvtrkitralgrikvglqtklflgnlqasrdwgfagdyveamwlmlqqek
pddyvvateeghtveefldvsfgylglnwkdyveidqryfrpaevdnlqgdaskakevlg
wkpqvgfeklvkmmvdedlelakrekvlvdagym

Timeline for d1n7hb_:

• d1n7hb_ first appeared in SCOP 1.63
  
• d1n7hb_ appears in SCOPe 2.07