SCOPe 2.08: Domain d1n5ox1: 1n5o X:1649-1757

Lineage for d1n5ox1 (1n5o X:1649-1757)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.15: BRCT domain [52112] (1 superfamily)
   3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134

4. Superfamily c.15.1: BRCT domain [52113] (6 families)
   Pfam PF00533

5. Family c.15.1.3: BRCT domain [63955] (1 protein)

6. Protein Breast cancer associated protein, BRCA1 [63956] (2 species)
   duplication: tandem repeat of BRCT domain

7. Species Human (Homo sapiens) [TaxId:9606] [63957] (15 PDB entries)
   Uniprot P38398 1649-1863

8. Domain d1n5ox1: 1n5o X:1649-1757 [80033]
   complexed with co, so4; mutant

Details for d1n5ox1

PDB Entry: 1n5o, 2.8 Å

PDB Description: structural consequences of a cancer-causing brca1-brct missense mutation

PDB Compounds: (X:) breast cancer type 1 susceptibility protein

SCOPe Domain Sequences for d1n5ox1:

Sequence, based on SEQRES records:

>d1n5ox1 c.15.1.3 (X:1649-1757) Breast cancer associated protein, BRCA1 {Human (Homo sapiens) [TaxId: 9606]}
rmsmvvsgltpeefmlvykfarkhhitltnliteetthvvmktdaefvcertlkyflgia
ggkwvvsyfwvtqsikerkmlnehdfevrgdvvngrnhqgpkraresqd

Sequence, based on observed residues (ATOM records):

>d1n5ox1 c.15.1.3 (X:1649-1757) Breast cancer associated protein, BRCA1 {Human (Homo sapiens) [TaxId: 9606]}
rmsmvvsgltpeefmlvykfarkhhitltnliteetthvvmktdafvcertlkyflgiag
gkwvvsyfwvtqsikerkmlnehdfevrgdvvngrnhqgpkraresqd

Timeline for d1n5ox1:

• d1n5ox1 first appeared in SCOP 1.63
  
• d1n5ox1 appears in SCOPe 2.07