SCOPe 2.08: Domain d1n2sa_: 1n2s A:

Lineage for d1n2sa_ (1n2s A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (2 species)

7. Species Salmonella typhimurium [TaxId:90371] [75103] (4 PDB entries)

8. Domain d1n2sa_: 1n2s A: [79857]
   complexed with mg, nai, trs
   has additional subdomain(s) that are not in the common domain

Details for d1n2sa_

PDB Entry: 1n2s, 2 Å

PDB Description: crystal structure of dtdp-6-deoxy-l-lyxo-4-hexulose reductase (rmld) in complex with nadh

PDB Compounds: (A:) dTDP-glucose oxidoreductase

SCOPe Domain Sequences for d1n2sa_:

Sequence; same for both SEQRES and ATOM records:

>d1n2sa_ c.2.1.2 (A:) dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) {Salmonella typhimurium [TaxId: 90371]}
mnillfgktgqvgwelqrslapvgnlialdvhskefcgdfsnpkgvaetvrklrpdvivn
aaahtavdkaesepelaqllnatsveaiakaanetgawvvhystdyvfpgtgdipwqetd
atsplnvygktklagekalqdncpkhlifrtswvyagkgnnfaktmlrlakerqtlsvin
dqygaptgaelladctahairvalnkpevaglyhlvaggtttwhdyaalvfdearkagit
laltelnavptsayptpasrpgnsrlntekfqrnfdlilpqwelgvkrmltemftttt

Timeline for d1n2sa_:

• d1n2sa_ first appeared in SCOP 1.63
  
• d1n2sa_ appears in SCOPe 2.07