SCOPe 2.08: Domain d1mr1a_: 1mr1 A:

Lineage for d1mr1a_ (1mr1 A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.26: SMAD/FHA domain [49878] (1 superfamily)
   sandwich; 11 strands in 2 sheets; greek-key

4. Superfamily b.26.1: SMAD/FHA domain [49879] (5 families)
   has a few short helices inserted in loops

5. Family b.26.1.1: SMAD domain [49880] (5 proteins)

6. Protein Smad4 tumor suppressor C-terminal domain [49881] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49882] (6 PDB entries)
   Uniprot Q13485 314-546

8. Domain d1mr1a_: 1mr1 A: [79418]
   Other proteins in same PDB: d1mr1c1, d1mr1c2, d1mr1d1, d1mr1d2
   complex with Ski
   complexed with zn

Details for d1mr1a_

PDB Entry: 1mr1, 2.85 Å

PDB Description: Crystal Structure of a Smad4-Ski Complex

PDB Compounds: (A:) Mothers against decapentaplegic homolog 4

SCOPe Domain Sequences for d1mr1a_:

Sequence, based on SEQRES records:

>d1mr1a_ b.26.1.1 (A:) Smad4 tumor suppressor C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
apeywcsiayfemdvqvgetfkvpsscpivtvdgyvdpsggdrfclgqlsnvhrteaier
arlhigkgvqleckgegdvwvrclsdhavfvqsyyldreagrapgdavhkiypsayikvf
dlrqchrqmqqqaataqaaaaaqaaavagnipgpgsvggiapaislsaaagigvddlrrl
cilrmsfvkgwgpdyprqsiketpcwieihlhralqlldevlhtm

Sequence, based on observed residues (ATOM records):

>d1mr1a_ b.26.1.1 (A:) Smad4 tumor suppressor C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
apeywcsiayfemdvqvgetfkvpsscpivtvdgyvdpsggdrfclgqlsnvhrteaier
arlhigkgvqleckgegdvwvrclsdhavfvqsyyldreagrapgdavhkiypsayikvf
dlrqchrqmqqqaataqaaaaaqvddlrrlcilrmsfvkgwgpdyprqsiketpcwieih
lhralqlldevlhtm

Timeline for d1mr1a_:

• d1mr1a_ first appeared in SCOP 1.63
  
• d1mr1a_ appears in SCOPe 2.07