SCOPe 2.03: Domain d1ma3a_: 1ma3 A:

Lineage for d1ma3a_ (1ma3 A:)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein AF0112, Sir2 homolog (Sir2-AF2) [82380] (1 species)

7. Species Archaeoglobus fulgidus [TaxId:2234] [82381] (3 PDB entries)

8. Domain d1ma3a_: 1ma3 A: [78883]
   complexed with an acetylated p53 peptide, chain B
   complexed with mes, zn

Details for d1ma3a_

PDB Entry: 1ma3, 2 Å

PDB Description: Structure of a Sir2 enzyme bound to an acetylated p53 peptide

PDB Compounds: (A:) Transcriptional regulatory protein, Sir2 family

SCOPe Domain Sequences for d1ma3a_:

Sequence, based on SEQRES records:

>d1ma3a_ c.31.1.5 (A:) AF0112, Sir2 homolog (Sir2-AF2) {Archaeoglobus fulgidus [TaxId: 2234]}
medeirkaaeilakskhavvftgagisaesgiptfrgedglwrkydpeevasisgfkrnp
rafwefsmemkdklfaepnpahyaiaelermgivkavitqnidmlhqragsrrvlelhgs
mdkldcldchetydwsefvedfnkgeiprcrkcgsyyvkprvvlfgeplpqrtlfeaiee
akhcdafmvvgsslvvypaaelpyiakkagakmiivnaeptmadpifdvkiigkagevlp
kiveevkrlrse

Sequence, based on observed residues (ATOM records):

>d1ma3a_ c.31.1.5 (A:) AF0112, Sir2 homolog (Sir2-AF2) {Archaeoglobus fulgidus [TaxId: 2234]}
medeirkaaeilakskhavvftgagisaeglwrkydpeevasisgfkrnprafwefsmem
kdklfaepnpahyaiaelermgivkavitqnidmlhqragsrrvlelhgsmdkldcldch
etydwsefvedfnkgeiprcrkcgsyyvkprvvlfgeplpqrtlfeaieeakhcdafmvv
gsslvvypaaelpyiakkagakmiivnaeptmadpifdvkiigkagevlpkiveevkrlr
se

Timeline for d1ma3a_:

• d1ma3a_ first appeared in SCOP 1.63
  
• d1ma3a_ appears in SCOPe 2.02
  
• d1ma3a_ appears in SCOPe 2.04
  
• d1ma3a_ appears in the current release, SCOPe 2.08