SCOP 1.65: Domain d1m2wa2: 1m2w A:1-192

Lineage for d1m2wa2 (1m2w A:1-192)

1. Root: SCOP 1.65

2. Class c: Alpha and beta proteins (a/b) [51349] (121 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

5. Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (12 proteins)
   the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
   C-terminal domains also show some similarity

6. Protein Mannitol 2-dehydrogenase [82301] (1 species)

7. Species Pseudomonas fluorescens [TaxId:294] [82302] (2 PDB entries)

8. Domain d1m2wa2: 1m2w A:1-192 [78503]
   Other proteins in same PDB: d1m2wa1, d1m2wb1

Details for d1m2wa2

PDB Entry: 1m2w, 1.8 Å

PDB Description: Pseudomonas fluorescens mannitol 2-dehydrogenase ternary complex with NAD and D-mannitol

SCOP Domain Sequences for d1m2wa2:

Sequence; same for both SEQRES and ATOM records:

>d1m2wa2 c.2.1.6 (A:1-192) Mannitol 2-dehydrogenase {Pseudomonas fluorescens}
mklnkqnltqlapevklpaytladtrqgiahigvggfhrahqayytdalmntgegldwsi
cgvglrsedrkarddlagqdylftlyelgdtddtevrvigsisdmllaedsaqalidkla
speirivsltiteggyciddsngefmahlpqiqhdlahpsspktvfgficaaltqrraag
ipaftvmscdnl

Timeline for d1m2wa2:

• d1m2wa2 first appeared in SCOP 1.63
  
• d1m2wa2 does not appear in SCOP 1.67