SCOP 1.73: Domain d1lwta1: 1lwt A:1-180,A:416-454

Lineage for d1lwta1 (1lwt A:1-180,A:416-454)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.86: Hedgehog/intein (Hint) domain [51293] (1 superfamily)
   complex fold made of five beta-hairpin units and a b-ribbon arc

4. Superfamily b.86.1: Hedgehog/intein (Hint) domain [51294] (2 families)
   duplication: contains two intertwined structural repeats

5. Family b.86.1.2: Intein (protein splicing domain) [51298] (4 proteins)

6. Protein VMA1-derived endonuclease (VDE) PI-Scei intein [51299] (1 species)
   also contains a homing endonuclease and DNA-binding domains

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51300] (8 PDB entries)

8. Domain d1lwta1: 1lwt A:1-180,A:416-454 [78278]
   Other proteins in same PDB: d1lwta2, d1lwta3
   complexed with mse

Details for d1lwta1

PDB Entry: 1lwt, 3.2 Å

PDB Description: Crystal structure of the intein homing endonuclease PI-SceI bound to its substrate DNA (Ca2+ free)

PDB Compounds: (A:) endonuclease pi-scei

SCOP Domain Sequences for d1lwta1:

Sequence, based on SEQRES records:

>d1lwta1 b.86.1.2 (A:1-180,A:416-454) VMA1-derived endonuclease (VDE) PI-Scei intein {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
cfakgtnvlmadgsiecienievgnkvmgkdgrpreviklprgretmysvvqksqhrahk
sdssrevpellkftcnathelvvrtprsvrrlsrtikgveyfevitfemgqkkapdgriv
elvkevsksypisegperanelvesyrkasnkayfewtieardlsllgshvrkatyqtya
Xcrgfyfelqelkeddyygitlsddsdhqfllanqvvvhn

Sequence, based on observed residues (ATOM records):

>d1lwta1 b.86.1.2 (A:1-180,A:416-454) VMA1-derived endonuclease (VDE) PI-Scei intein {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
cfakgtnvlmadgsiecienievgnkvmgkdgrpreviklprgretmysvvqksqhrahk
ssrevpellkftcnathelvvrtprsvrrlsrtikgveyfevitfemgqkkapdgrivel
vkevsksypisegperanelvesyrkasnkayfewtieardlsllgshvrkatyqtyaXc
rgfyfelqelkeddyygitlsddsdhqfllanqvvvhn

Timeline for d1lwta1:

• d1lwta1 first appeared in SCOP 1.63
  
• d1lwta1 appears in SCOP 1.71
  
• d1lwta1 appears in SCOP 1.75
  
• d1lwta1 appears in the current release, SCOPe 2.08