SCOPe 2.08: Domain d1lwsa1: 1lws A:1-180,A:416-454

Lineage for d1lwsa1 (1lws A:1-180,A:416-454)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.86: Hedgehog/intein (Hint) domain [51293] (1 superfamily)
   complex fold made of five beta-hairpin units and a b-ribbon arc

4. Superfamily b.86.1: Hedgehog/intein (Hint) domain [51294] (3 families)
   duplication: contains two intertwined structural repeats

5. Family b.86.1.2: Intein (protein splicing domain) [51298] (5 proteins)

6. Protein VMA1-derived endonuclease (VDE) PI-Scei intein [51299] (1 species)
   also contains a homing endonuclease and DNA-binding domains

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51300] (8 PDB entries)
   Uniprot P17255 284-737

8. Domain d1lwsa1: 1lws A:1-180,A:416-454 [78275]
   Other proteins in same PDB: d1lwsa2, d1lwsa3
   protein/DNA complex; complexed with ca

Details for d1lwsa1

PDB Entry: 1lws, 3.5 Å

PDB Description: Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence

PDB Compounds: (A:) endonuclease pi-scei

SCOPe Domain Sequences for d1lwsa1:

Sequence, based on SEQRES records:

>d1lwsa1 b.86.1.2 (A:1-180,A:416-454) VMA1-derived endonuclease (VDE) PI-Scei intein {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
cfakgtnvlmadgsiecienievgnkvmgkdgrpreviklprgretmysvvqksqhrahk
sdssrevpellkftcnathelvvrtprsvrrlsrtikgveyfevitfemgqkkapdgriv
elvkevsksypisegperanelvesyrkasnkayfewtieardlsllgshvrkatyqtya
Xcrgfyfelqelkeddyygitlsddsdhqfllanqvvvhn

Sequence, based on observed residues (ATOM records):

>d1lwsa1 b.86.1.2 (A:1-180,A:416-454) VMA1-derived endonuclease (VDE) PI-Scei intein {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
cfakgtnvlmadgsiecienievgnkvmgkdgrpreviklprgretmysvvqksqhrahk
sdssrevpellkftcnathelvvrtprsvrrlsrtikgvfevitfemgqkkapdgrivel
vkevsksypisperanelvesyrkasnkayfewtieardlsllgshvrkatyqtyaXcrg
fyfelqelkeddyygitlsddsdhqfllanqvvvhn

Timeline for d1lwsa1:

• d1lwsa1 first appeared in SCOP 1.63
  
• d1lwsa1 appears in SCOPe 2.07