Lineage for d1lwfa2 (1lwf A:1-429)

  1. Root: SCOP 1.71
  2. 617324Class e: Multi-domain proteins (alpha and beta) [56572] (48 folds)
  3. 618192Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
    divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
  4. 618193Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families) (S)
    "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain
  5. 618312Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)
  6. 618313Protein HIV-1 reverse transcriptase [56689] (2 species)
  7. 618314Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (83 PDB entries)
  8. 618380Domain d1lwfa2: 1lwf A:1-429 [78271]
    Other proteins in same PDB: d1lwfa1
    complexed with csd, nvp; mutant

Details for d1lwfa2

PDB Entry: 1lwf (more details), 2.8 Å

PDB Description: crystal structure of a mutant hiv-1 reverse transcriptase (rtmq+m184v: m41l/d67n/k70r/m184v/t215y) in complex with nevirapine

SCOP Domain Sequences for d1lwfa2:

Sequence, based on SEQRES records: (download)

>d1lwfa2 e.8.1.2 (A:1-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpv
faikkknstrwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqyvddlyvgsdleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlakllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyql

Sequence, based on observed residues (ATOM records): (download)

>d1lwfa2 e.8.1.2 (A:1-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpv
faikklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkyt
aftipnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqyvddlyvgs
dleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwtvqpivlpekds
wtvndiqklvgklnwasqiypgikvrqlakllrgtkalteviplteeaelelaenreilk
epvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqltea
vqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql

SCOP Domain Coordinates for d1lwfa2:

Click to download the PDB-style file with coordinates for d1lwfa2.
(The format of our PDB-style files is described here.)

Timeline for d1lwfa2:

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Domains from same chain:
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d1lwfa1
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Domains from other chains:
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d1lwfb_