SCOP 1.69: Domain d1lweb_: 1lwe B:

Lineage for d1lweb_ (1lwe B:)

1. Root: SCOP 1.69

2. Class e: Multi-domain proteins (alpha and beta) [56572] (46 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (78 PDB entries)

8. Domain d1lweb_: 1lwe B: [78269]
   Other proteins in same PDB: d1lwea1

Details for d1lweb_

PDB Entry: 1lwe, 2.81 Å

PDB Description: crystal structure of m41l/t215y mutant hiv-1 reverse transcriptase (rtmn) in complex with nevirapine

SCOP Domain Sequences for d1lweb_:

Sequence, based on SEQRES records:

>d1lweb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
etvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfr
kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymd
dlyvgsdleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwtvqpiv
lpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelae
nreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndv
kqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
wyq

Sequence, based on observed residues (ATOM records):

>d1lweb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
etvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfiphpaglkkkksvtvldvgdayfsvpldedfrkytaft
ipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgs
dleigqhrtkieelrqhllrwglyyelhpdkwtvqpivlpekdswtvndiqklvgklnwa
sqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdlia
eiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktp
kfklpiqketwetwwteywqatwipewefvntpplvklwyq

Timeline for d1lweb_:

• d1lweb_ first appeared in SCOP 1.63
  
• d1lweb_ appears in SCOP 1.67
  
• d1lweb_ appears in SCOP 1.71
  
• d1lweb_ appears in the current release, SCOPe 2.08